{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:39:33Z","timestamp":1773189573932,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>There is limited research on management of metastatic anal canal squamous cell carcinoma (SCC) to the liver. This study aimed to describe outcomes for patients undergoing liver resection of anal SCC metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, retrospective cohort study was conducted by three tertiary\u2010referral centers. Patients undergoing liver surgery between 2008 and 2022 were included. Cox regression analysis was performed to evaluate predictors of recurrence and survival and Kaplan\u2013Meier analysis was performed for 1\u2010, 3\u2010, and 5\u2010year survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients underwent liver resection and\/or ablation. None were HIV positive and 24% had known HPV infection. 20\/21(95%) patients had undergone Nigro protocol for management of the primary tumor with 12\/21 (57%) patients experiencing complete response. 4\/21 (19%) patients had synchronous liver metastases at time of diagnosis. Median tumor size was 5.0\u2009cm and median tumor number was one. At analysis, 52% remained alive. Median overall survival was 32.2 months. 5\u2010year overall survival was 50%. Median recurrence\u2010free survival was 7.7 months and 5\u2010year recurrence\u2010free survival was 30%. Need for salvage abdominoperineal resection was negatively associated with recurrence\u2010free survival. The most common site of recurrence was the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver resection for metastatic anal SCC can be beneficial for appropriately selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27539","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T08:41:38Z","timestamp":1701247298000},"page":"568-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term overall survival in patients undergoing liver resection for metastatic anal squamous cell carcinoma"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6943-6164","authenticated-orcid":false,"given":"Winifred M.","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania 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A.","family":"Geller","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.08.016"},{"key":"e_1_2_8_3_1","volume-title":"NCCN Guidelines Version 2.2022 Anal Carcinoma Continue NCCN Guidelines Panel Disclosures","author":"Benson AB","year":"2022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2022.08.032"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-247470"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2015.11.02"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"30","article-title":"Combined multimodal approach to the treatment of metastatic anal carcinoma: report of a case and review of the 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