{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T07:15:24Z","timestamp":1753600524371,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Up to 60% of incidentally detected gallbladder cancers (GBCs) have a primary stage of pathologic T2 stage (pT2), defined by invasion of the peri\u2010adventitial tissue by the tumour, a plane breached during a simple cholecystectomy. This study assesses the impact of incidental detection of pT2 GBCs on survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of pT2 GBCs undergoing a curative resection was performed. Patients who received neoadjuvant chemotherapy before an upfront radical resection were excluded. Outcomes of patients undergoing upfront surgery (uGBC) and incidentally detected tumours (iGBC) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 1356 patients, 425 patients with pT2 GBCs were included. Of these, 118 (27.7%) and 307 (72.23%) patients were in the uGBC and iGBC groups, respectively. Patients with iGBC had significantly higher locoregional, (62 [19.8%]\u00a0vs. 11 [9.3%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.009), liver, (36 [11.5%]\u00a0vs. 4 [3.4%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and abdominal wall recurrences (23 [7.4%]\u00a0vs. 1 [0.8%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.009). Five\u2010year disease free survival\u00a0rates were 68.7% and 49.2% in the uGBC and iGBC groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.013). Five\u2010year overall survival\u00a0rates were 71.7% and 64.6% in the uGBC and iGBC groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.317).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Incidentally detected pT2 GBCs have significantly poorer outcomes compared to similarly staged patients undergoing an upfront radical cholecystectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27562","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T10:59:38Z","timestamp":1702465178000},"page":"754-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of incidental versus non\u2010incidental T2 gallbladder cancer: A single\u2010institute experience of 425 cases"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-6825","authenticated-orcid":false,"given":"Shraddha","family":"Patkar","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, GI &amp; 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