{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:55:29Z","timestamp":1776354929707,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This study aimed to evaluate the postoperative complications associated with administering intravenous (IV) tranexamic acid (TXA) in patients undergoing surgical fixation for neoplastic pathologic fractures of the lower extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients \u226518 years old who underwent surgical intervention for neoplastic pathologic lower extremity fractures from 2015 to 2021 were identified using the Premier Healthcare Database. This cohort was divided by TXA receipt on the index surgery day. Patient demographics, hospital factors, patient comorbidities, and 90\u2010day complications were assessed and compared between the cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2015 to 2021, 4497 patients met inclusion criteria (769 TXA[+] and 3728 TXA[\u2212]). Following propensity score matching, patients who received TXA had a significantly shorter length of stay than those who did not (7.6\u2009\u00b1\u20097.3 days vs. 9.0\u2009\u00b1\u200915.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.036). Between the two cohorts, there were no significant differences in comorbidities. Regarding differences in postoperative complications, TXA(+) patients had significantly decreased odds of deep vein thrombosis (DVT) (1.87% vs. 5.46%; odds ratio [OR]:0.33; 95% confidence interval: 0.17\u20130.62; <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of IV TXA may be associated with a decreased risk of postoperative DVT without an increased risk of other complications. Orthopedic surgeons should consider the utilization of IV TXA in patients treated surgically for neoplastic pathologic fractures of the lower extremity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27601","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T13:49:53Z","timestamp":1708609793000},"page":"1150-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intravenous tranexamic acid reduces complications following surgical treatment of pathologic fractures of the lower extremity"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-9289","authenticated-orcid":false,"given":"Brandon S.","family":"Gettleman","sequence":"first","affiliation":[{"name":"University of South Carolina School of Medicine Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Chen","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arad","family":"Talehakimi","sequence":"additional","affiliation":[{"name":"Kansas City University College of Osteopathic Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California 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