{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:50:50Z","timestamp":1794124250352,"version":"4.8.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The extent of pelvic lymphadenectomy (PLND) as part of radical cystectomy (RC) for bladder cancer (BC) remains unclear. Sentinel\u2010based and lymphangiographic approaches could lead to reduced morbidity without sacrificing oncologic safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the feasibility and diagnostic value of fluorescence\u2010guided template sentinel region dissection (FTD) using a handheld near\u2010infrared fluorescence (NIRF) camera in open radical cystectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>After peritumoral cystoscopic injection of indocyanine green (ICG) 21 patients underwent open RC with FTD due to BC between June 2019 and June 2021. Intraoperatively, the FIS\u201000 Hamamatsu Photonics\u00ae NIRF camera was used to identify and resect fluorescent template sentinel regions (FTRs) followed by extended pelvic lymphadenectomy (ePLND) as oncological back\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome Measurement and Statistical Analysis<\/jats:title><jats:p>Descriptive analysis of positive and negative results per template region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Limitations<\/jats:title><jats:p>FTRs were identified in all 21 cases. Median time (range) from ICG injection to fluorescence detection was 75 (55\u2013125) minutes. On average (SD), 33.4 (9.6) lymph nodes were dissected per patient. Considering template regions as the basis of analysis, 67 (38.3%) of 175 resected regions were NIRF\u2010positive, with 13 (7.4%) regions harboring lymph node metastases. We found no metastatic lymph nodes in NIRF\u2010negative template regions. Outside the standard template, two NIRF\u2010positive benign nodes were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The concept of NIRF\u2010guided FTD proved for this group all lymph node metastases to be found in NIRF\u2010positive template regions. Pending validation in a larger collective, resection of approximately 40% of standard regions may be sufficient and may result in less morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27618","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T16:04:37Z","timestamp":1712505877000},"page":"1325-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Near\u2010infrared fluorescence lymph node template region dissection plus backup lymphadenectomy in open radical cystectomy for bladder cancer using an innovative handheld device: A single center experience"],"prefix":"10.1002","volume":"129","author":[{"given":"Lukas","family":"P\u00fcllen","sequence":"first","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro F.","family":"Costa","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"},{"name":"Department of Nuclear Medicine West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Darr","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kesch","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rehme","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Wahl","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leubet","family":"Yirga","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Reis","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt, University Hospital Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Szarvas","sequence":"additional","affiliation":[{"name":"Department of Urology West German Cancer Center University Duisburg Essen, University Hospital Essen Essen Germany"},{"name":"German Cancer Consortium (DKTK) Heidelberg Germany"},{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt, University Hospital Frankfurt Frankfurt am Main Germany"},{"name":"Department of Urology Faculty of Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fijs W. 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