{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:17:06Z","timestamp":1775913426473,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We examined the effect of disease\u2010free interval (DFI) duration on cancer\u2010specific mortality (CSM)\u2010free survival, otherwise known as the effect of conditional survival, in radical urethrectomy nonmetastatic primary urethral carcinoma (PUC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Surveillance, Epidemiology, and End Results (SEER) database 2000\u20132020, patient (age, sex, race\/ethnicity, and marital status) and tumor (stage and histology) characteristics, as well as systemic therapy exposure status of nonmetastatic PUC patients were tabulated. Conditional survival estimates at 5\u2010year were assessed based on DFI duration and according to stage at presentation (T<jats:sub>1 \u20132<\/jats:sub>N<jats:sub>0<\/jats:sub> vs. T<jats:sub>3\u20134<\/jats:sub>N<jats:sub>0\u20132<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all 512 radical urethrectomy PUC patients, 278 (54%) harbored T<jats:sub>1\u20132<\/jats:sub>N<jats:sub>0<\/jats:sub> stage versus 234 (46%) harbored T<jats:sub>3\u20134<\/jats:sub>N<jats:sub>0\u20132<\/jats:sub> stage. In 512 PUC patients, 5\u2010year CSM\u2010free survival at initial diagnosis was 61.8%. Provided a DFI duration of 36 months, 5\u2010year CSM\u2010free survival was 85.6%. In 278 T<jats:sub>1\u20132<\/jats:sub>N<jats:sub>0<\/jats:sub> PUC patients, 5\u2010year CSM\u2010free survival at initial diagnosis was 68.4%. Provided a DFI duration of 36 months, 5\u2010year CSM\u2010free survival was 86.9%. In 234 T<jats:sub>3\u20134<\/jats:sub>N<jats:sub>0\u20132<\/jats:sub> PUC patients, 5\u2010year CSM\u2010free survival at initial diagnosis was 53.8%. Provided a DFI duration of 36 months, 5\u2010year CSM\u2010free survival was 83.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although intuitively, clinicians and patients are well aware of the concept that increasing DFI duration improves survival probability, only a few clinicians can accurately estimate the magnitude of survival improvement, as was done within the current study. Such information is crucial to survivors, especially in those diagnosed with rare malignancies, where the survival estimation according to DFI duration is even more challenging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27637","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T08:33:35Z","timestamp":1712910815000},"page":"1348-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Contemporary conditional cancer\u2010specific survival rates in surgically treated nonmetastatic primary urethral carcinoma"],"prefix":"10.1002","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-8569","authenticated-orcid":false,"given":"Simone","family":"Morra","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Scheipner","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IRCCS Policlinico San Donato Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia M. I.","family":"Jannello","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IEO European Institute of Oncology, IRCCS Milan Italy"},{"name":"Department of Urology Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Experimental Oncology\/Unit of Urology URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Siech","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology University Hospital Frankfurt, Goethe University Frankfurt am Main Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawar","family":"Touma","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Comprehensive Cancer Center, Medical University of Vienna Vienna Austria"},{"name":"Department of Urology Weill Cornell Medical College New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas Texas USA"},{"name":"Hourani Center of Applied Scientific Research Al\u2010Ahliyya Amman University Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Creta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Califano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Celentano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-7341","authenticated-orcid":false,"given":"Claudia","family":"Colla' 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