{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:55:52Z","timestamp":1792634152998,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The adequacy of the cut end of the mandible following a segmental mandibulectomy done for oral cancer intraoperatively is at times assessed using a frozen section (FS)\u00a0of the bone marrow (BM)\u00a0at the cut ends. The study aimed to assess its utility to guide the intraoperative decision on the adequacy of bony margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All patients with oral squamous cell carcinoma (OSCC)\u00a0who underwent segmental mandibulectomy from January 2012 to December 2021 at our institute and for whom intraoperative FS of BM was utilized were included. We analyzed the sensitivity, specificity, and positive and negative predictive value (PPV,\u00a0NPV) of this in predicting positive bone margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 457 patients were included in the study. The majority of the cases were per premium cases (<jats:italic>n<\/jats:italic>\u2009=\u2009372, 81.4%). The median age of the cohort was 52 years (range: 22\u201380 years). Most patients had T4 disease (<jats:italic>n<\/jats:italic>\u2009=\u2009406, 88.8%). On FS, BM was positive in only 18 patients (3.9%) for whom the bone margin was revised. BM biopsy report in the final histopathology was positive in 12 patients (2.2%). The sensitivity, specificity PPV, and NPV were 52.3%, 98.65%, 64.7%, and 97.7% respectively. No factors predicting BM positivity on FS could be identified in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The BM FS was positive in only a small percentage of patients, and it helped in reducing the bone margin positivity rate from 3.9% to 2.2% only. Hence the intraoperative BM FS seems to have limited utility as seen from our study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27659","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:33:37Z","timestamp":1714455217000},"page":"1501-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does the use of intraoperative frozen section of bone marrow from the cut end of the mandible help assess the adequacy of bone margins following mandibulectomy for oral cancer?"],"prefix":"10.1002","volume":"129","author":[{"given":"Kaushik","family":"Polusany","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Tata Memorial Centre and Homi Bhabha National Institute (HBNI) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Karun","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Tata Memorial Centre and Homi Bhabha National Institute (HBNI) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapnil","family":"Rane","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Centre and Homi Bhabha National Institute (HBNI) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-3338","authenticated-orcid":false,"given":"Shivakumar","family":"Thiagarajan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology,\u00a0Division of Head &amp; Neck Tata Memorial Centre and Homi Bhabha National Institute (HBNI) Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.01.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2017.03.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000516"},{"key":"e_1_2_8_5_1","first-page":"790","article-title":"Intraoperative microwave processing of bone margins during resection of head and neck cancer","volume":"127","author":"Weisberger EC","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.01.068"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_41_18"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00310-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(94)90024-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25063"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21350"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199505000-00004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(97)90060-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.26710"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.09.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0264-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21428"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.07.010"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:24:46Z","timestamp":1723199086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jso.27659"],"URL":"https:\/\/doi.org\/10.1002\/jso.27659","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"assertion":[{"value":"2023-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}