{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:06:03Z","timestamp":1779879963026,"version":"3.53.1"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastrointestinal stromal tumors (GISTs) are sarcomas affecting the stomach and small intestine, with a rare subtype characterized by succinate dehydrogenase B (SDHB)\u2010loss posing significant diagnostic and therapeutic challenges. A 62\u2010year\u2010old man with weight loss and abdominal pain was diagnosed with a gastric GIST showing SDHB\u2010loss. Initial treatment with Imatinib reduced the tumor size, but surgery revealed no residual tumor. Despite adjuvant Imatinib, recurrence occurred, necessitating further surgical intervention. While GISTs typically benefit from surgery and tyrosine kinase inhibitors (TKIs), those with SDHB\u2010loss are resistant to TKIs, requiring a different management approach. This case emphasizes the importance of surgical intervention for SDHB\u2010deficient GISTs and the need for ongoing research into effective treatments for this subtype.<\/jats:p>","DOI":"10.1002\/jso.27727","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T06:19:12Z","timestamp":1722838752000},"page":"741-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrence of fusocellular subtype GIST with SDHB mutation: A case of SDHB\u2010loss and therapeutic challenges"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-0885","authenticated-orcid":false,"given":"Samuel","family":"da Silva Gomes","sequence":"first","affiliation":[{"name":"General Surgery Deparment Hospital Felicio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina S.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"General Surgery Deparment Hospital Felicio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago de Almeida","family":"Furtado","sequence":"additional","affiliation":[{"name":"General Surgery Deparment Hospital Felicio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M.","family":"Melo","sequence":"additional","affiliation":[{"name":"General Surgery Deparment Hospital Felicio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara G.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"General Surgery Deparment Hospital Felicio Rocho Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata S. 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