{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:08:05Z","timestamp":1788566885517,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of the current study was to characterize prognostic factors related to long\u2010term recurrence\u2010free survival after curative\u2010intent resection of intrahepatic cholangiocarcinoma (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on patients who underwent curative\u2010intent resection for ICC between 2000 and 2020 were collected from an international multi\u2010institutional database. Prognostic factors were investigated among patients who recurred within 5 years versus long\u2010term survivors who survived more than 5 years with no recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 635 patients who underwent curative\u2010intent resection for ICC, 104 (16.4%) patients were long\u2010term survivors with no recurrence beyond 5 years after surgery. Patients who survived for more than 5 years with no recurrence were more likely to have less aggressive tumor features, as well as have undergone an R0 resection versus patients who recurred within 5 years after resection. On multivariable analysis, tumor size (&gt;5\u2009cm) (HR: 1.535, 95% CI: 1.254\u20131.879), satellite lesions (HR: 1.253, 95% CI: 1.003\u20131.564), and lymph node metastasis (HR: 1.733, 95% CI: 1.349\u20132.227) were independently associated with recurrence within 5 years. Patients who recurred beyond 5 years (<jats:italic>n<\/jats:italic>\u2009=\u200923), 2\u20135 years (<jats:italic>n<\/jats:italic>\u2009=\u200960), and within 2 years (<jats:italic>n<\/jats:italic>\u2009=\u2009471) had an incrementally worse post\u2010recurrence survival (PRS, 28.0 vs. 20.0 vs. 12.0 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.032). Among patients with N0 status, tumor size (&gt;5\u2009cm) (HR: 1.612, 95% CI: 1.087\u20132.390) and perineural invasion (PNI) (HR: 1.562,95% CI: 1.081\u20132.255) were risk factors associated with recurrence. Among patients with N1 disease, only a minority (5\/128, 3.9%) of patients survived with no recurrence to 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Roughly 1 in 6 patients survived for more than 5 years with no recurrence following curative\u2010intent resection of ICC. Among N0 patients, tumor recurrence was associated with tumor size and PNI. Only a small subset of N1 patients experienced long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27739","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:34:29Z","timestamp":1718778869000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term survivors after curative\u2010intent resection for intrahepatic cholangiocarcinoma"],"prefix":"10.1002","volume":"130","author":[{"given":"Zhi\u2010Jie","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Xi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Institute of Advanced Surgical 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