{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:28:42Z","timestamp":1792114122733,"version":"4.4.0"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous melanoma (CM) is a malignancy with a variable incidence worldwide and a poor advanced\u2010stage prognosis. Melanoma growth is closely associated with the immune system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed on CM patients admitted at the Hospital de Cancer de Pernambuco (HCP) between 2015 and 2018. Fifty\u2010one CM patients were included, and 30 healthy individuals. The study aimed to evaluate the association of platelet activation mechanisms and inflammatory response in patients with cutaneous melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elevated serum IL10 and low serum TNF levels in CM patients compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). High IL6 levels in patients with negative lymph nodes LN (\u2212) compared to positive lymph nodes group (LN\u2009+, <jats:italic>p<\/jats:italic>\u2009=\u20090.0005). Low RANTES levels in patients compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Elevated levels of platelet\u2010lymphocyte (PLA), platelet\u2010monocytes (PMA), and platelet\u2010neutrophils (PNA) aggregates were observed in patients compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). CM patients with stage II had lower PMA levels than stages I and III (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). High PMA levels were observed in patients with LN (+) compared to the LN (\u2010) group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Patients with SSM had high levels of sCD40L and sCD62P compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05)). High sCD40L levels in stage II compared to the stage III group, and sCD62P in stages I and II compared to the stage III group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). High sCD62P levels in patients with LN (\u2010) compared to the group LN (+) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was observed the immunosuppressive profile in CM may favor tumor progression. High levels of platelet\u2010leukocyte aggregates, sCD40L, and sCD62P may be associated with the worst prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27748","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T06:24:36Z","timestamp":1723443876000},"page":"869-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the expression of cytokines and chemokines, platelet\u2010leukocyte aggregates, sCD40L and sCD62P in cutaneous melanoma"],"prefix":"10.1002","volume":"130","author":[{"given":"Rogerio Luiz dos","family":"Santos","sequence":"first","affiliation":[{"name":"Translational Research Laboratory Prof. CA Hart (IMIP) Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) Recife Brazil"},{"name":"Hospital de C\u00e2ncer de Pernambuco Recife Brazil"},{"name":"Skin Cancer Department A.C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-8210","authenticated-orcid":false,"given":"M\u00e1rio R.","family":"Martins","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory Prof. CA Hart (IMIP) Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) Recife Brazil"},{"name":"Hospital de C\u00e2ncer de Pernambuco Recife Brazil"},{"name":"Skin Cancer Department A.C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Lobo","family":"Tavares","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory Prof. CA Hart (IMIP) Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) Recife Brazil"},{"name":"Hospital de C\u00e2ncer de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedreira Duprat","family":"Neto","sequence":"additional","affiliation":[{"name":"Skin Cancer Department A.C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leuridan Cavalcante","family":"Torres","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory Prof. CA Hart (IMIP) Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) Recife Brazil"},{"name":"Hospital de C\u00e2ncer de Pernambuco Recife Brazil"},{"name":"Postgraduate program in Translational Medicine, Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","unstructured":"Erratum in. CA Cancer J Clin.2024;74(2):203.doi:10.3322\/caac.21820","DOI":"10.3322\/caac.21830"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.15"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_10_5_1","unstructured":"WolffK JohnsonR SaavedraAP RohEK et al.Melanoma precursors and primary cutaneous melanoma. In:Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology 8e.McGraw\u2010Hill Education;2017. Accessed August 5 2024.https:\/\/accessemergencymedicine.mhmedical.com\/Content.aspx?bookid=2043&sectionid=154898647"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.7724"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805053181804"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410280036004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001001)89:7<1495::AID-CNCR12>3.0.CO;2-D"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11272"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70283-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/BD-2004-20103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1582"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11037"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1316"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3789"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314617.118"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202500"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050946"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00129"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0604337"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.14.1693"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/768758"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9847-0"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2160"},{"key":"e_1_2_10_30_1","article-title":"Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy","volume":"2013","author":"Bremer E","year":"2013","journal-title":"ISRN Oncol"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.01.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1067"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-009-1199-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3164"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu082"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0669-2"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091320"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-016-9826-6"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-186585"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067416"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095588"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2272"},{"key":"e_1_2_10_43_1","first-page":"773","article-title":"Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I\u20105\u2010iodo\u20102\u2032\u2010deoxyuridine","volume":"45","author":"Fidler IJ","year":"1970","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00047.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-11-0654"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.167601"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.6.891"},{"key":"e_1_2_10_49_1","first-page":"16","article-title":"The role of tumor necrosis factor in health and disease","volume":"57","author":"Beutler BA","year":"1999","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200385"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-325225"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209285"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1400530"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000146147.89667.ed"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1402"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63238-5"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.469"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960529)66:5<607::AID-IJC4>3.0.CO;2-X"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e318158795b"},{"key":"e_1_2_10_60_1","first-page":"3537","article-title":"Evaluation of IL\u20102, IL\u20106, IL\u20108 and IL\u201010 in malignant melanoma diagnostics","volume":"35","author":"Kucera R","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200506000-00009"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9332"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.01.008"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90008-U"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/292376"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690164"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3004"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1430358"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040855"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201103"},{"key":"e_1_2_10_71_1","first-page":"679","article-title":"Endothelial P\u2010selectin expression is reduced in advanced primary melanoma end melanoma metastasis","volume":"152","author":"Nooijen PT","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2016.1153619"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T05:15:39Z","timestamp":1732252539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,11]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jso.27748"],"URL":"https:\/\/doi.org\/10.1002\/jso.27748","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,11]]},"assertion":[{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}