{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:48:48Z","timestamp":1793047728093,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited understanding exists regarding early sarcoma symptoms presented during general practitioner\u00a0(GP) consultations. The study explores GP visit patterns and recorded diagnoses in the 12 months preceding sarcoma diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sarcoma cases diagnosed from 2010 to 2020 were identified through the Netherlands Cancer Registry alongside general practice data. Sarcoma cases were age and gender matched to cancer\u2010free controls (2:1 or 1:1 ratio).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 787 individuals with soft\u2010tissue sarcoma (STS)\u00a0and 188 individuals with bone sarcoma (BS)\u00a0were identified. There was a significant difference in monthly GP contacts from 4 months to the last month before STS diagnosis, and 2 months before BS diagnosis between cases and controls. Most prevalent diagnoses recorded by the GP for STS cases included musculoskeletal neoplasm (26.6%), uncomplicated hypertension (15.6%), and cystitis\/other urinary infections (12.2%). For BS cases, musculoskeletal neoplasm (42.8%), knee symptoms\/complaints (9.7%), and shoulder symptoms\/complaints (9.7%) were most frequent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Discussion<\/jats:title>\n                    <jats:p>A significant difference in GP contacts between cases and controls preceding sarcoma diagnosis. STS cases were predominantly diagnosed with nonspecific symptoms, whereas BS cases with diagnoses more suggestive of BS. Better understanding of the prediagnostic trajectory could aid GPs in early identification of sarcoma<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27757","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:34:06Z","timestamp":1719801246000},"page":"265-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The prediagnostic general practitioner care of sarcoma patients: A real\u2010world data study"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-4553","authenticated-orcid":false,"given":"Emily I.","family":"Holthuis","sequence":"first","affiliation":[{"name":"Medical Oncology Department NKI\u2010AVL \u2010 Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winette T. A.","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"Medical Oncology Department NKI\u2010AVL \u2010 Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Medical Oncology, Erasmus MC Cancer Institute Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cas","family":"Drabbe","sequence":"additional","affiliation":[{"name":"Medical Oncology Department NKI\u2010AVL \u2010 Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"},{"name":"Department of Primary and Community Care, Radboud Institute of Medical Innovation Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winan J.","family":"van Houdt","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department NKI\u2010AVL \u2010 Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"Schrage","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department NKI\u2010AVL \u2010 Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C. 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