{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:00:17Z","timestamp":1785045617198,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leiomyosarcoma of the vena cava (LMS\u2010VC)\u00a0is a rare entity with poor oncological outcomes and a lack of histological staging prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes of consecutive patients operated on LMS\u2010VC\u00a0between March 2003 and May 2022, in two specialized sarcoma centers were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Forty\u2010one patients were identified. Median size of LMS\u2010VC\u00a0was 9\u2009cm with 68% of complete obstruction. After surgery, severe complication rate was 30%. No postoperative mortality was reported. Microscopic complete excision was obtained for 71% of patients, R1 for 27% and one patient presented an R2 resection. Grade 3 was found in 24%. After a median follow\u2010up of 70 months, 3 years disease\u2010free\u00a0survival (DFS) and 5 years DFS were 34% and 17%, and 3 years\u00a0overall survival (OS)\u00a0and 5 years OS were 74% and 50%. Distant metastasis concerned 54% of recurrences, local 7% and local and distant 5%. Multivariate analysis showed that FNCLCC grade (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and perioperative chemotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.026) were significant factors for DFS. In multivariate analysis, FNCLCC grade was a significant factor for OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Perioperative chemotherapy may have a role to play in lowering the risk of recurrence for LMS\u2010VC,\u00a0particularly in high\u2010grade tumor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27765","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:04:33Z","timestamp":1720415073000},"page":"552-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vena cava leiomyosarcoma surgery results in a retrospective cohort of 41 patients from two centers"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6126-2246","authenticated-orcid":false,"given":"Thibaud","family":"Bertrand","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Gustave 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