{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:23Z","timestamp":1740104843178,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This study compares surgical and oncological outcomes in patients with Crohn's disease (CD)\u2010related colorectal cancer (CRC) to those with sporadic CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated between 1983 and 2013 were matched by stage, age, gender, American Society of Anesthesiologists (ASA), cancer site, and adjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For stages I and II, 107 patients were matched (58.9% male, mean age 59 years, 59.8% with ASA score 3). Tumor sites included the right (17.7%), transverse (4.7%), left colon (15.9%), and rectum (61.7%). CD patients exhibited longer operative times, higher pT stages, and 2.60 times the odds of postoperative complications (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Overall and disease\u2010free survival were similar.<\/jats:p><jats:p>For stage III, 54 patients were matched (57.4% male, mean age 54 years, 46.3% with ASA score 3). The cancer site distribution was right (29.7%), transverse (3.7%), left colon (18.5%), and rectum (48.1%). CD patients had longer operative times, increased blood loss, more involved lymph nodes, higher pT\u2010 and pN\u2010stages. The rates of postoperative complications were not different (<jats:italic>p<\/jats:italic>\u2009=\u20090.19). CD\u2010related CRC patients had similar overall (<jats:italic>p<\/jats:italic>\u2009=\u20090.06), and local recurrence\u2010free survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite facing worse perioperative and pathological characteristics, survival differences in stages I\u2013III CD\u2010related CRC compared with sporadic CRC patients were not significantly different.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27768","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T05:44:20Z","timestamp":1721022260000},"page":"644-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Crohn's disease\u2010related versus sporadic colorectal cancer: A stage\u2010matched case\u2010control study based on four decades of experience"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7819-4883","authenticated-orcid":false,"given":"Lukas","family":"Schabl","sequence":"first","affiliation":[{"name":"Department for Colorectal Surgery, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara M.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Department for Colorectal Surgery, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane Gouvea Monteiro","family":"de Camargo","sequence":"additional","affiliation":[{"name":"Department for Colorectal Surgery, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himani","family":"Sancheti","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences 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