{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:12:59Z","timestamp":1789017179454,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment guidelines provided by PRODIGE\u20107 recommend perioperative systemic chemotherapy before cytoreductive surgery (CRS) for colorectal cancer peritoneal metastases (CRPM). Toxicity with multimodal treatment needs to be better defined. Chemotherapy response and impact on survival have not been reported. We assessed CRPM patients who received systemic oxaliplatin\/irinotecan before CRS (preoperative) with Mitomycin C (35\u2009mg\/m<jats:sup>2<\/jats:sup>, 90\u2009min) or Oxaliplatin (368\u2009mg\/m<jats:sup>2<\/jats:sup>, 30\u2009min) heated intraperitoneal chemotherapy\u00a0(HIPEC). Secondary analysis was performed from a prospective database. Overall survival (OS) in chemotherapy responders (R) and nonresponders (NR) was compared. Toxicity was assessed by rate of adverse events (AEs). From April 2005 to April 2021, 436 patients underwent CRS\u2009+\u2009HIPEC; 125 (29%) received preoperative chemotherapy. The 112 (90%) received oxaliplatin (64, 57%) or irinotecan (48, 43%). R, defined as complete (CR) or partial response\u00a0on preoperative imaging and\/or postoperative histology, was seen in 71, 63% (53.8\u201372.3); 16, 14% (8.4\u201322.2) had CR. Median OS in R versus\u00a0NR was 43.7 months (37.9\u201349.4) versus 23.9 (16.3\u201331.4) <jats:italic>p<\/jats:italic>\u2009=\u20090.007, HR 0.51 (0.31\u20130.84). OS multivariable analysis showed HR 0.48 (0.25\u20100.95), <jats:italic>p<\/jats:italic>\u2009=\u20090.03 for chemotherapy response corrected by\u00a0peritoneal cancer index, completeness of cytoreduction score. CRS led to 21% grade 3\u20134 AEs versus 4% for preoperative chemotherapy. HIPEC grade 3\u20104 AEs were 0.5%. Preoperative chemotherapy response is an independent predictor for OS in CRPM.<\/jats:p>","DOI":"10.1002\/jso.27776","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T10:43:36Z","timestamp":1721126616000},"page":"1422-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative chemotherapy response and survival in patients with colorectal cancer peritoneal metastases"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1877-658X","authenticated-orcid":false,"given":"Nadina","family":"Tinsley","sequence":"first","affiliation":[{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK"},{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.","family":"O'Dwyer","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK"},{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendar","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health University of Manchester Manchester UK"},{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipasha","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Braun","sequence":"additional","affiliation":[{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saifee","family":"Mullamitha","sequence":"additional","affiliation":[{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kamposioras","sequence":"additional","affiliation":[{"name":"Christie Peritoneal Oncology Centre (CPOC) at The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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