{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:11Z","timestamp":1786978271862,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Hepatic epithelioid hemangioendothelioma (HEHE) is an uncommon vascular neoplasm characterized by variable clinical behavior. Our aim was to describe the therapeutic approach for HEHE at diagnosis and define clinicopathological characteristics associated with tumor progression and long\u2010term survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study that includes patients with HEHE who received treatment at Mayo Clinic Rochester between 1984 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients were included in the study (median age: 44 years; 62.5% female), 24 underwent liver transplantation, 26 underwent liver resection, and 30 were managed medically. The 3\u2010year overall survival rates were 86.7%, 80.9%, and 51.1%, respectively. Notably, 26 patients had extrahepatic metastases at the time of diagnosis, four (16.7%) in the transplantation group, four (15.4%) in the resection group, and 18 (69.2%) in the nonsurgical group. On multivariable modeling, bone metastasis was independently associated with long\u2010term mortality (HR 6.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) while lung metastasis and surgical intervention were not associated with long\u2010term mortality (HR 0.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8; HR 1.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bone metastasis emerged as a strong predictor of poor survival. Hence, aggressive surgical intervention may not be advantageous in patients with skeletal metastases but can still be offered for those with other extrahepatic metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27807","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T02:15:54Z","timestamp":1727230554000},"page":"1062-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Management and Long\u2010Term Outcomes of Patients With Hepatic Epithelioid Hemangioendothelioma"],"prefix":"10.1002","volume":"130","author":[{"given":"Tedy","family":"Sawma","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmer","family":"Sultan","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Abdulmoneim","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-097X","authenticated-orcid":false,"given":"Travis","family":"Grotz","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timucin","family":"Taner","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Heimbach","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne G.","family":"Warner","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany L.","family":"Siontis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh P.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven I.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius A.","family":"Thiels","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820901)50:5<970::AID-CNCR2820500527>3.0.CO;2-Z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<562::AID-CNCR7>3.0.CO;2-T"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-4-269"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22530"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80145-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22225"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00213.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.11.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i18.3978"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11128"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100170"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3807"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1729-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1236134"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002246"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500050612"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198912000-00001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881115)62:10<2079::AID-CNCR2820621002>3.0.CO;2-J"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.tb00429.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0247-3"},{"key":"e_1_2_10_22_1","first-page":"1673","article-title":"Epithelioid Hemangioendothelioma of the Liver Associated With Thrombocytopenia and Coagulopathy","volume":"49","author":"Imanishi H.","year":"2002","journal-title":"Hepato\u2010gastroenterology"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.27807","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:41:08Z","timestamp":1773812468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jso.27807"],"URL":"https:\/\/doi.org\/10.1002\/jso.27807","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2024-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}