{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:24:15Z","timestamp":1792506255400,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Solid pseudopapillary neoplasm (SPN) of the pancreas demonstrates an indolent disease course; however, some patients present with a \u201cmalignant\u201d phenotype, including distant metastases resistant to chemotherapy. This analysis identifies molecular drivers of metastatic SPN using the world's largest clinicogenomics database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange was queried for primary and metastatic SPN samples. Sample\u2010level genomic alterations were compared. A pan\u2010pancreatic cancer analysis assessed relevant mutations among all metastatic pancreatic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 28 SPN samples identified (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917 primary,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911 metastatic), the most commonly mutated gene was\n                      <jats:italic>CTNNB1,<\/jats:italic>\n                      (24\/28 samples; 85.7%). Most mutations were missense (21\/24; 87.5%) or in\u2010frame deletions (3\/24; 12.5%). The most common\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      mutations in primary SPN were exon 3 S37F\/C missense mutations (6\/16 profiled patients, 37.5%), contrasting exon 3 D32N\/Y\/H missense mutations in metastatic samples (6\/11 profiled patients, 54.5%). Metastatic SPN had higher rates of\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      mutations than metastases from pancreatic ductal adenocarcinoma (72.7% vs. 1.1%;\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.0001), pancreatic neuroendocrine tumor (72.7% vs. 2.5%;\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and pancreatic acinar cell carcinoma (72.7% vs. 11.5%;\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u20090.0254).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Missense mutations along exon 3 of\n                      <jats:italic>CTNNB1<\/jats:italic>\n                      predominate metastatic SPN, differentiating these patients from those with metastases from analogous pancreatic malignancies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27808","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:38:47Z","timestamp":1724038727000},"page":"1051-1061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>CTNNB1<\/i>\n                    exon 3 mutations in metastatic solid pseudopapillary neoplasm of the pancreas"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-9014","authenticated-orcid":false,"given":"Andrew M.","family":"Fleming","sequence":"first","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Gehle","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Pedo","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah E.","family":"Hendrick","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Oncology H. Lee Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Yakoub","sequence":"additional","affiliation":[{"name":"Department of Surgery Augusta University Medical Center Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafeez","family":"Abdelhafeez","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosratollah","family":"Nezakatgoo","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah L.","family":"Deneve","sequence":"additional","affiliation":[{"name":"Department of Surgery University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max R.","family":"Langham","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-0542","authenticated-orcid":false,"given":"Evan S.","family":"Glazer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center Memphis Tennessee USA"},{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee 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