{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:27:59Z","timestamp":1747150079974,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (PPIs) negatively impact fluoropyrimidine\u2010based chemotherapy efficacy in colorectal cancer. This study assessed PPI impact on major pathologic response (mPR) rates of pancreatic adenocarcinoma (PDAC) patients receiving fluoropyrimidine\u2010based chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An institutional retrospective review of resected PDAC patients receiving neoadjuvant fluoropyrimidine\u2010based chemotherapy (98% FOLFIRINOX) from 2011 to 2021 was conducted. Outcomes were stratified by use or nonuse of PPIs within 6 months of neoadjuvant chemotherapy initiation. Primary outcome was mPR defined as complete or near complete response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 540 patients included, the median age was 64 (IQR: 60\u201370) years, 297 (55%) were male, and 202 (37%) were PPI users. 170 (31%) patients had mPR with similar rates among PPI users and nonusers (29% vs. 33%, <jats:italic>p<\/jats:italic>\u2009=\u20090.38). No difference in mPR was seen between PPI users and nonusers receiving chemoradiation (35% vs. 36%, <jats:italic>p<\/jats:italic>\u2009=\u20090.89) or \u22658 cycles of NAC (33% vs. 36%, <jats:italic>p<\/jats:italic>\u2009=\u20090.55). Median OS for PPI users was 30.9 versus 31.7 months for nonusers (<jats:italic>p<\/jats:italic>\u2009=\u20090.62). On multivariable analysis, PPI therapy was not associated with decreased survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPI usage did not significantly influence mPR or OS following neoadjuvant fluoropyrimidine\u2010based chemotherapy in resected PDAC patients. Further analysis of all patients, not just those who underwent resection, is required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27837","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T07:10:36Z","timestamp":1726038636000},"page":"1634-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of proton pump inhibitors on pathologic response rates following fluoropyrimidine\u2010based neoadjuvant chemotherapy in pancreatic cancer patients"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-7809","authenticated-orcid":false,"given":"Jessica A.","family":"Steadman","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmer","family":"Sultan","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney N.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie A.","family":"Parish","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Cancer Care Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne G.","family":"Warner","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Kendrick","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; Pancreas Surgery, Department of Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Truty","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary &amp; 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