{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:28:04Z","timestamp":1740104884391,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This paper presents the ongoing studies regarding HIPEC, as found on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety trials have been identified, and the protocols of 15 studies have been presented in detail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are interesting ongoing trials investigating the role of CRS plus HIPEC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27853","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:40:01Z","timestamp":1730702401000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relevant Ongoing Clinical Trials to Investigate Local\u2010Regional Treatment Strategies for Peritoneal Surface Malignancies"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-9797","authenticated-orcid":false,"given":"S.","family":"Blaj","sequence":"first","affiliation":[{"name":"Department of General and Visceral Surgery Hospital Barmherzige Br\u00fcder Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"H\u00e4usler","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Nathanstift Hospital F\u00fcrth  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-4505","authenticated-orcid":false,"given":"P.","family":"Piso","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery Hospital Barmherzige Br\u00fcder Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30599-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21519"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02867"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"J.\u2010M.Classe P.Meeus E.Leblanc et al. Hyperthermic Intraperitoneal Chemotherapy in Platinum\u2010Sensitive Relapsed Epithelial Ovarian Cancer: The CHIPOR Randomized Phase III Trial (June 2024) https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2023.41.16_suppl.5510.","DOI":"10.1200\/JCO.2023.41.16_suppl.5510"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.1642"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-023-13116-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1070362"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143430"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:34:43Z","timestamp":1739511283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jso.27853"],"URL":"https:\/\/doi.org\/10.1002\/jso.27853","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}