{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:55:34Z","timestamp":1793912134376,"version":"4.8.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared the predictive performance of the 7th and 8th editions of the AJCC staging systems in stratifying disease\u2010related survival outcomes in patients with GBC undergoing curative intent surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients that underwent curative intent surgery for GBC at our institution (2014 and 2021) were included in the study. Various clinico\u2010pathological data were extracted to perform Kaplan\u2013Meier survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 240 patients were included in the study. Both, TNM\u20107, and TNM\u20108 staging systems can stratify patients into stages with statistically significant differences in disease\u2010free and overall survival. Survival rates drop with stage progression. Using TNM\u20108, 8\/240 (3.33%) patients were upstaged from Stage IIIB (TNM\u20107) to IVB (TNM\u20108) and 12\/240 (5%) were down\u2010staged from Stage IVB(TNM\u20107) to IIIB(TNM\u20108). Survival curves of the re\u2010classified patients matched those of the corresponding TNM\u20108 stage. Additionally, there was statistically significant difference in their survival (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to their corresponding TNM\u20107 stage. There was no statistically significant difference in survival rates between stages IIA, IIB (TNM\u20108), and stage II (TNM\u20107). However, stage IIA had a slightly better survival than stage IIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Though both TNM\u20107 and TNM\u20108 are useful for stratifying patients with GBC, TNM\u20108 has a better prognostic performance than TNM\u20107.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27875","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T06:56:57Z","timestamp":1726037817000},"page":"220-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Prognostic Performance of 8th and 7th Edition of AJCC Staging System for Patients With Gallbladder Cancer Undergoing Curative Intent Surgery"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1865-1640","authenticated-orcid":false,"given":"Sameer","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"},{"name":"Vice\u2010Chancellor Atal Bihari Vajpayee Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-3248","authenticated-orcid":false,"given":"Naseem","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology King George's Medical University Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makayla","family":"Schissel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-8898","authenticated-orcid":false,"given":"Chandrakanth","family":"Are","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fred and Pamela Buffett Cancer Center, Division of Surgical Oncology University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2019.85166"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051249"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4_15"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"65","article-title":"A Simple Sequentially Rejective Multiple Test Procedure","volume":"6","author":"Holm S.","year":"1979","journal-title":"Scandinavian Journal of Statistics"},{"key":"e_1_2_8_8_1","first-page":"92","article-title":"[Note on the Possible Role of the International Union against Cancer in Nomenclature, Classification, Analytical Index, Bibliography and Documentation]","volume":"8","author":"Denoix P. 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