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Presently, there is no standardized HIPEC protocol with respect to chemotherapeutic agent, dose, administration temperature, or duration and limited literature comparing outcomes in different regimens. In this study, we analyze common practices and outcomes of published HIPEC regimens to gain insight into current practice to inform future directions of study. We conducted a literature search for investigational studies of CRS and HIPEC for MPM treatment in adults and identified 35 such articles. These studies were analyzed for institution type and location, drug regimens, perfusion temperatures and time, and study outcomes including median survival, complication rates, and perioperative mortality rates. On review, there is significant heterogeneity in HIPEC regimens and outcome reporting metrics, suggesting a need for multi\u2010institutional standardized study protocols to better determine the safest and most efficacious treatment regimen.<\/jats:p>","DOI":"10.1002\/jso.27882","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T06:29:09Z","timestamp":1726036149000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perfusion Strategies for Cytoreductive Surgery With Heated Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma"],"prefix":"10.1002","volume":"131","author":[{"given":"Claire","family":"Drigotas","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander 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