{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:23Z","timestamp":1786978163385,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Peritoneal metastasis from colorectal cancer carries a high risk for relapse after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\u2010HIPEC). A novel alpha\u2010emitting radiopharmaceutical (Radspherin) has been designed to deliver short\u2010range radiation to micrometastases and free\u2010floating tumor cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Phase 1\/2a study evaluated the safety, tolerability, and signal of efficacy of escalating doses of Radspherin injected intraperitoneally after CRS\u2010HIPEC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven patients received 1\u22124\u2009MBq (Group 1) whereas 12 patients received 7\u2009MBq; nine patients single dose\/three patients split\u2010dose (Group 2). Median age was 66.5 and 61.5 years, and median peritoneal cancer index 6 and 7, respectively. One hundred and seventy\u2010eight adverse events were reported, only seven were deemed related to Radspherin. Thirteen serious adverse events (SAEs) were reported in eight patients and no SAEs were related to Radspherin. At 18\u2010months, none of the 12 patients receiving 7\u2009MBq experienced peritoneal recurrences, however four had non\u2010peritoneal recurrences. Across both groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), 41% had recurrent disease, only 14% of them in the peritoneum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radspherin was well tolerated. At 18 months, median disease\u2010free survival has not been reached, and none of the patients receiving the recommended dose (7\u2009MBq) had peritoneal recurrences. The results are encouraging and warrant further clinical evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27897","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:19:30Z","timestamp":1729477170000},"page":"1395-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Eighteen\u2010Months Safety and Efficacy Following Intraperitoneal Treatment With\n                    <sup>224<\/sup>\n                    Radium\u2010Labeled Microparticles After CRS\u2010HIPEC in Patients With Peritoneal Metastasis From Colorectal Cancer"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-1995","authenticated-orcid":false,"given":"S. G.","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Oncological Surgery, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University Uppsala Sweden"},{"name":"Department of Surgery Uppsala Academic Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Sciencons A\/S Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010E.","family":"Revheim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Clinical Medicine University of Oslo Oslo Norway"},{"name":"The Intervention Centre Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Mariathasan","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-1203","authenticated-orcid":false,"given":"O.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Spasojevic","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Radiology, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lundstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Uppsala Academic Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Gjertsen","sequence":"additional","affiliation":[{"name":"Oncoinvent ASA Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010K.","family":"Aksnes","sequence":"additional","affiliation":[{"name":"Oncoinvent ASA Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-3733","authenticated-orcid":false,"given":"\u00d8. S.","family":"Bruland","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Oncology, Norwegian Radium Hospital Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30500-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24290"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30599-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03525-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01620-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.419"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1070362"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13050634"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874471013666201201102056"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1165747"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-689"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181afde41"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9635-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6279-3"},{"issue":"6","key":"e_1_2_10_18_1","first-page":"693","article-title":"Abdominal Metastases From Colorectal Cancer: Intraperitoneal Therapy","volume":"6","author":"Guend H.","year":"2015","journal-title":"Journal of Gastrointestinal Oncology"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05467-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248133"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1058914"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231192902"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:34:40Z","timestamp":1739493280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,20]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jso.27897"],"URL":"https:\/\/doi.org\/10.1002\/jso.27897","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,20]]},"assertion":[{"value":"2024-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}