{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:48:18Z","timestamp":1785797298785,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To analyze the cytokine profile in cerebrospinal fluid (CSF), as well as mood, anxiety, and cognition profiles in patients with CC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and nine individuals were evaluated, 37 controls, 18 CWC, and 54 CC patients. Assessments included BDI, HADS, Digit Span, FAS\u2010verbal, Animals\/WMS\u2010R, Matrix Reasoning and Vocabulary (WASI), and QLQ\u2010C30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CC group exhibited 62.96% depression and probable anxiety\/depression, with 75.92% showing attention deficits. The CC and CWC groups demonstrated significant cognitive impairment on the WASI\u2010Vocabulary test (CWC: 13.4\u2009\u00b1\u20092.2; CC: 15.9\u2009\u00b1\u20091.1) compared to the control group (Ct: 22.8\u2009\u00b1\u20091.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.0002). In the QLQ\u2010C30 scores, the CC group reported a greater perceived loss of quality of life and health deterioration (score of 17.5\u2009\u00b1\u20092.6) and lower scores on the Functional Scale (49.8\u2009\u00b1\u20094.5). The CC group had 18.52% illiteracy, 18.52% incomplete higher education, and 22.22% complete elementary education. The CC group also had lower weight (Ct: 67.8\u2009\u00b1\u20091.4; CWC: 61.7\u2009\u00b1\u20093.1; CC: 59.6\u2009\u00b1\u20091.7; <jats:italic>p<\/jats:italic>\u2009=\u20090.0023) and BMI (CC: 21.5 [18.3; 24.8]; Ct: 24.9 [23; 25.8]; <jats:italic>p<\/jats:italic>\u2009=\u20090.0021) compared to controls. Cytokines detected in the CSF were MCP\u20101, VEGF, IL\u20108, IP\u201010, and MIP\u20101\u03b2. Higher concentrations of MCP\u20101 were found in cancer patients (CSC: 571.2\u2009\u00b1\u2009105.8; CC: 399.5\u2009\u00b1\u200965.9; Ct: 1477\u2009\u00b1\u20090.1; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), along with lower levels of MIP\u20101\u03b2 (CC: 4345 [3060; 7353]) and VEGF (CC: 48.3\u2009\u00b1\u20092.0; CWC: 49.8\u2009\u00b1\u20093.8; Ct: 64.8\u2009\u00b1\u20093.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The level of mental impairment (mood, anxiety, and cognitive deficits) correlated with cancer\u2010associated and cachexia\u2010associated inflammation, weight loss, low BMI, elevated C\u2010reactive protein (CRP), leukocytosis, lymphopenia, anemia, hypoalbuminemia, and low scores on the QLQ\u2010C30 questionnaire (Global Health Status, Functional Scale, Symptom Scale). The CC group exhibited a higher prevalence of depression\/anxiety, a stronger correlation between depression and inflammation, and greater cognitive impairment in attention, reasoning, and language, alongside lower average educational attainment. The low concentration of certain cytokines in the CSF combined with elevated systemic CRP in cancer and cachexia, associated with mental disorders, presents a paradox that requires further investigation. Higher concentrations of the cytokine MCP\u20101 in cancer patient groups indicated a positive correlation with the preservation of language abilities in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27912","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:04:11Z","timestamp":1727427851000},"page":"965-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mood, Anxiety, and Cognitive Alterations in Cancer Patients"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-3981","authenticated-orcid":false,"given":"Gabriela Noronha","family":"Fortes","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Fraga","family":"Fortes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Noronha","family":"Fortes","sequence":"additional","affiliation":[{"name":"Universidade Santo Amaro S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Christoffel","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Santo Amaro S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Cerqueira Leite","family":"Seelaendar","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariene Murari Soares","family":"de Pinho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce de Cassia Rosa","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pinhata","family":"Otoch","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Kaplan & Sadock\u2014Comp\u00eandio de psiquiatria: ci\u00eancia do comportamento e psiquiatria cl\u00ednica, recurso eletr\u00f4nico","author":"Sadock B. 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