{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:58:09Z","timestamp":1768874289478,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, there is a paucity of data that describes the length of time required to realize improvement in pain and function following surgery for patients with metastatic cancer to bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred patients with impending or completed pathologic fractures due to metastatic cancer to bone were enrolled in this prospective cohort study. Outcomes were measured with a Computer Adaptive Test of Patient Reported Outcomes for Pain Interference and Physical Function domains, to determine the time required to achieve a Minimal Clinically Important Difference (MCID) in the tested domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010one patients were included in the analysis. Thirty\u2010two patients (39.5%) survived and completed the follow\u2010up to 1 year, while 23 (28.4%) died before the end of the data collection. Fifty\u2010one patients (63.0%) achieved at least a 5\u2010point improvement in Physical Function and 59 (72.8%) achieved at least a 5\u2010point improvement in Pain Interference. The time to achieve the MCID was 6 weeks for the Physical Function and 4 weeks for the Pain Interference domain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of patients with impending or completed pathologic fractures due to metastatic cancer see clinically important improvements in pain and function after surgery in an average of 4 and 6 weeks, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27932","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:07:42Z","timestamp":1732838862000},"page":"955-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Length of Time to Clinical Improvement After Orthopedic Oncology Surgery in Patients With Metastatic Cancer: A Multi\u2010Institution Patient\u2010Reported Outcome Study"],"prefix":"10.1002","volume":"131","author":[{"given":"John","family":"Groundland","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Hart","family":"Tokson","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-2617","authenticated-orcid":false,"given":"Amy","family":"Cizik","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Blank","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Rush University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Colorado Limb Consultants Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Utah Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-774X","authenticated-orcid":false,"given":"R. 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