{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:32:09Z","timestamp":1791664329669,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We evaluate the impact of frailty and malnutrition on breast cancer surgery outcomes in older adults using the ACS 5\u2010factor modified frailty index (MFI) and Global Leadership Initiative on Malnutrition (GLIM) definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single institution retrospective review of a prospective database of the older adult (&gt;60 years old) breast cancer surgery patients (2000\u20132016); cases stratified into groups as per MFI (0\u20132) and GLIM. Characteristics, 90\u2010day post\u2010op events, and 5\u2010year follow\u2010up data were analyzed to report survival and complication outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 436 patients at diagnosis, 213 (48.9%) were &gt;80 years old. 377 (86.5%) were alive at 5 years. 274 (62.8%) had MFI\u2009&gt;\u20090, and 69 (15.8%) had malnutrition. Patients\u2009\u2265\u200980, MFI\u2009&gt;\u20090, and PR\u2010negative tumors had worse 5\u2010year survival. There was no survival difference in patients &gt;80 with\/without malnutrition (HR\u2009=\u20091.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.971), and there was no difference in mastectomy or lumpectomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.560) between patients\u2009\u2265\u200980 or patients younger than 80; however, 94% of immediate reconstruction were in pts\u2009&lt;\u200980. On multivariate regression, complications were associated with age\u2009&lt;\u200980, readmission, MFI\u2009&gt;\u20090, and history of HTN; serious complications were associated with age\u2009&lt;\u200980, readmission, anticoagulation, and not receiving endocrine therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MFI showed a significant predictive value for 5\u2010year survival for patients\u2009\u2265\u200980 and should be part of the preoperative evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27940","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:50:31Z","timestamp":1728557431000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frailty and Malnutrition in Surgical Outcomes of Elderly Breast Cancer Patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-5874","authenticated-orcid":false,"given":"Diego","family":"Hanssen","sequence":"first","affiliation":[{"name":"Comprehensive Breast Program Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Champion","sequence":"additional","affiliation":[{"name":"Breast Surgery GenesisCare Venice Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Ngo","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Palfi","sequence":"additional","affiliation":[{"name":"University of South Florida Morsani College of Medicine Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Whiting","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Bioinformatics Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Sun","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Laronga","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sam","sequence":"additional","affiliation":[{"name":"Senior Adult Oncology Program Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Comprehensive Breast Program Moffitt Cancer Center Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh414"},{"key":"e_1_2_8_3_1","unstructured":"\u201cCancer Stat facts: Female Breast Cancer \u201d Surveillance Epidemiology and End Results Program (SEER) accessed April 13 2024 https:\/\/seer.cancer.gov\/statfacts\/html\/breast.html."},{"key":"e_1_2_8_4_1","unstructured":"\u201cBreast Cancer Facts & Figs. 2022\u20132024 \u201d American Cancer Society accessed April 1 2024 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