{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:04:20Z","timestamp":1774281860923,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The oncologic benefit of liver resection for colorectal liver metastases (CRLM) in the setting of concurrent extrahepatic disease (EHD) is controversial. We performed a population\u2010based, cross\u2010sectional study to determine the practice patterns and overall survival (OS) of patients with CRLM\u2009+\u2009EHD who underwent liver resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CRLM\u2009+\u2009EHD were identified using the California Cancer Registry from 2000 to 2019. Records were linked to the Office of Statewide Health Planning Inpatient Database. Patient demographics, clinical characteristics, and survival were compared between CRLM\u2009+\u2009EHD patients with and without liver resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 170\u2009978 patients with CRLM, 62\u2009003 (36%) had concurrent EHD (CRLM\u2009+\u2009EHD). In all, 3736 (6%) of CRLM\u2009+\u2009EHD underwent liver resection compared to 22% of patients with liver limited CRLM. Compared to CRLM\u2009+\u2009EHD without liver resection, CRLM\u2009+\u2009EHD with resection were younger, had fewer comorbidities, received higher frequencies of perioperative chemotherapy, and were more likely to have only a single site of EHD rather than multiple sites. Median OS was significantly higher for CRLM\u2009+\u2009EHD with resection compared to without (52 vs. 27 months, HR 0.46 [95% CI 0.44\u20130.47],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Regarding the location of EHD, this survival benefit was observed with liver resection for lung, peritoneal, intraabdominal lymph nodes, ovarian, and bone metastases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large population\u2010based setting, subsets of CRLM\u2009+\u2009EHD patients that undergo liver resection are associated with prolonged survival. These results support surgery with thoughtful patient selection to optimize survival outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27944","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T14:16:32Z","timestamp":1730124992000},"page":"443-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Liver Resection With Extrahepatic Disease: A Population\u2010Based Analysis of Thoughtful Selection"],"prefix":"10.1002","volume":"131","author":[{"given":"Kelly M.","family":"Mahuron","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-2702","authenticated-orcid":false,"given":"Matthew C.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H. G.","family":"Ituarte","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-2226","authenticated-orcid":false,"given":"Mustafa","family":"Raoof","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-9959","authenticated-orcid":false,"given":"Yuman","family":"Fong","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-7981","authenticated-orcid":false,"given":"Laleh G.","family":"Melstrom","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery City of Hope National Medical Center Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2021.11.017"},{"key":"e_1_2_8_5_1","unstructured":"\u201cColon Cancer (Version 2.2023) \u201d National Comprehensive Cancer Network 2023 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