{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T04:11:18Z","timestamp":1768363878320,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Lymphedema treatment has traditionally focused on region\u2010specific interventions. However, recent evidence suggests otherwise. This study aims to evaluate whether the benefits of liposuction for lymphedema are confined to the treated limb or extend to other areas of the body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent liposuction for extremity lymphedema between January and June 2023 at Cleveland Clinic were included in the study. Patients with less than 1\u2010year follow\u2010up or incomplete post\u2010operative tracking studies were excluded. Pre\u2010 and post\u2010operative evaluations included patient report, 3D volumetric measurements, and indocyanine green lymphography (ICGL). Liposuction was performed under general anesthesia with circumferential removal of pathological bulk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight limbs in 36 patients (33 females, 3 males, mean age 58 years) underwent surgery. All reported marked improvements, with some noting the improvements as \u201clife\u2010changing.\u201d Improvements in lymphatic functions were observed in all operative limbs (38) and non\u2010operative contralateral limbs (38), with an average volume reduction of 30.0% and 19.5%, respectively. ICGL further confirmed improved lymphatic drainage in all limbs (76).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liposuction, traditionally considered a region\u2010specific treatment for lymphedema, exerts therapeutic effects beyond the surgical site, suggesting broader systemic benefits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.27985","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T09:38:33Z","timestamp":1731317913000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Debulking Lymphatic Liposuction: Are the Therapeutic Effects Limited to the Treated Limb?"],"prefix":"10.1002","volume":"131","author":[{"given":"Shih\u2010Lun","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Center for Lymphedema Research and Reconstruction Cleveland Clinic Cleveland Ohio USA"},{"name":"Division of Plastic Surgery, Department of Surgery Cathay General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melis","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Center for Lymphedema Research and Reconstruction Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Center for Lymphedema Research and Reconstruction Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010815)92:4 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