{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:51:14Z","timestamp":1770497474151,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Both malignancy and orthopedic surgery are known risk factors for developing venous thromboembolism (VTE). Therefore, this study aimed to compare VTE rates among patients receiving enoxaparin, apixaban, rivaroxaban, or aspirin (ASA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Premier Healthcare Database was utilized to identify all patients who underwent surgery for neoplastic pathologic fractures of the lower extremities from 2015 to 2021. Four cohorts based on receipt of ASA, apixaban, enoxaparin, or rivaroxaban were identified. Propensity matching with the enoxaparin cohort as the comparator was performed. Patient demographics, hospital factors, comorbidities, and 90\u2010day complications were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2015 to 2021, 3762 patients underwent surgical intervention for neoplastic pathologic fracture of the lower extremities. Enoxaparin recipients showed significantly lower aggregate VTE rates than those on apixaban (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) while exhibiting higher VTE occurrence than ASA\u2010treated patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.050).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates that the administration of enoxaparin in patients undergoing surgical intervention for neoplastic pathologic fractures of the lower extremities may lead to significantly higher rates of aggregate VTE postoperatively compared to ASA. This data suggests that further research is warranted to determine if surgeons may safely consider using ASA in patients with no other reported risk factors or need for anticoagulation postoperatively, even in active malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.27997","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T01:35:52Z","timestamp":1732671352000},"page":"942-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Aspirin Safe for Thromboprophylaxis After Surgery for Lower Extremity Neoplastic Pathologic Fractures?"],"prefix":"10.1002","volume":"131","author":[{"given":"Matthew S.","family":"Chen","sequence":"first","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-9289","authenticated-orcid":false,"given":"Brandon S.","family":"Gettleman","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arad","family":"Talehakimi","sequence":"additional","affiliation":[{"name":"Kansas City University College of Osteopathic Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Menendez","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander B.","family":"Christ","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California, Los Angeles Los Angeles California USA"},{"name":"Department of Surgery VA Greater Los Angeles Healthcare System Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B12.BJJ-2019-1136.R3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21645"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.21.00711"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.01067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B9.30905"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199805)68:1<41::AID-JSO9>3.0.CO;2-L"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26499"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26601"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21603"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2003.10.003"},{"key":"e_1_2_8_13_1","first-page":"2768","article-title":"Evaluation of Efficacy and Safety of Rivaroxaban in the Prevention of Postoperative Venous Thromboembolism in Adult Patients With Primary Bone Tumor Undergoing Knee Operation","volume":"92","author":"Tang B.\u2010Q.","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250096"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000975"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2021.1891751"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002944"},{"key":"e_1_2_8_18_1","volume-title":"\"Premier Healthcare Database: Data That Informs and Performs\"","author":"PA Sciences","year":"2020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13416"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60880-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800374"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00147"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610928008827941"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2404"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2022.5.n2083"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02764.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712746"},{"key":"e_1_2_8_29_1","first-page":"1552","article-title":"Comparison of Warfarin, Low\u2010Molecular\u2010Weight Dextran, Aspirin, and Subcutaneous Heparin in Prevention of Venous Thromboembolism Following Total Hip Replacement","volume":"56","author":"Harris W. H.","year":"1974","journal-title":"Journal of Bone & Joint Surgery"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.21499"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"Major Extremity Trauma Research Consortium (METRC) R. V. O'Toole D. M. Stein et al. \u201cAspirin or Low\u2010Molecular\u2010Weight Heparin for Thromboprophylaxis After a Fracture \u201d New England Journal of Medicine 388 (2023): 203\u2013213.","DOI":"10.1056\/NEJMoa2205973"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.00253"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.900059"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-012-0987-y"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.27997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:46:09Z","timestamp":1763225169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.27997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jso.27997"],"URL":"https:\/\/doi.org\/10.1002\/jso.27997","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"2024-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}