{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:51:29Z","timestamp":1792497089821,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Neurogenic bladder (NB), a complication of gynecological cancer treatment, entails significant symptoms such as loss of urinary urgency, incontinence, and renal dysfunction. To investigate whether lymphatic fluid stagnation at the pelvis causes NB, we investigated the effectiveness of lymphaticovenular anastomosis (LVA) for NB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study between 2014 and April 2024, LVA was performed on 52 patients complaining of preoperative urinary dysfunction with lower extremity lymphedema following pelvic lymphadenectomy in gynecologic cancer treatment. Pre\u2010 and postoperative assessments evaluated NB symptoms and volume reduction of lower extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With an average follow\u2010up period of 35.0 months, the volume of the affected limbs was reduced in all patients. Symptoms of urinary function were improved in 44 out of 52 patients, as improved urinary urgency, disappearance of incontinence, and independence from self\u2010catheterization. Among 15 patients who underwent pre\u2010 and postoperative questionnaire assessment of NB, the mean score of NB severity decreased significantly from 16.9\u2009\u00b1\u20097.1 points preoperatively to 4.3\u2009\u00b1\u20093.6 points postoperatively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The specific reason for NB following gynecologic cancer treatment remains unclear. Our study results suggest that lymphatic fluid stagnation itself might be a reason for NB and LVA could reduce these symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.28000","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:03:50Z","timestamp":1731499430000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lymphaticovenular Anastomosis as a Treatment for Neurogenic Bladder in Patients With Lower Extremity Lymphedema After Gynecologic Cancer Treatment"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-483X","authenticated-orcid":false,"given":"Yukio","family":"Seki","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer Research Koto\u2010Ku Tokyo Japan"},{"name":"Department of Plastic and Reconstructive Surgery St. Marianna University School of Medicine Kawasaki Kanagawa Japan"},{"name":"Department of Plastic and Reconstructive Surgery Shonan Atsugi Hospital Atsugi Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhito","family":"Okino","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery St. Marianna University School of Medicine Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Tokai University School of Medicine Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer Research Koto\u2010Ku Tokyo 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