{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:12Z","timestamp":1786978152508,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The watch\u2010and\u2010wait (WW) strategy in patients after complete clinical response (cCR) following chemoradiotherapy for locally advanced rectal cancer (LARC) offers the option of organ preservation. The aim of this study was to assess the oncological outcomes of WW patients treated and followed up in a German referral cancer center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed the clinical records of consecutive patients with LARC who underwent neoadjuvant radiotherapy\/chemoradiotherapy at our institution between January 2020 and December 2023 and received non\u2010operative management after cCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 30 patients undergoing WW for LARC were included. After a median follow\u2010up of 17 months (SD\u2009=\u200910 months), local regrowth occurred in four patients (4\/30, 13.3%), and one patient (1\/30, 3.3%) developed distant metastasis. No predictor for tumor regrowth could be identified based on radiological findings at diagnosis, including cT4 and\/or cN2, involvement of the mesorectal fascia, extramural vascular invasion or infiltration of the anal sphincter\/levator. All patients with local regrowth were successfully surgically treated (R0 resection).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nonoperative management for patients with cCR after neoadjuvant therapy for LARC proved to be safe. R0 resection was successfully achieved in all patients who underwent salvage surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.28001","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T23:44:15Z","timestamp":1731627855000},"page":"658-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Watch\u2010and\u2010Wait Approach Following Neoadjuvant Chemo\u2010Radiotherapy for Locally Advanced Rectal Cancer: A Retrospective Single\u2010Center Cohort Study"],"prefix":"10.1002","volume":"131","author":[{"given":"Georgi","family":"Kalev","sequence":"first","affiliation":[{"name":"Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Buettner","sequence":"additional","affiliation":[{"name":"Department of Biometry and Statistics, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzuo","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf\u2010Dieter","family":"Hofheinz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Boda\u2010Heggemann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Reissfelder","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi","family":"Vassilev","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-3776","authenticated-orcid":false,"given":"Julia","family":"Hardt","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040694"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000141194.27992.32"},{"key":"e_1_2_9_3_2","doi-asserted-by":"crossref","unstructured":"discussion717\u2013718 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Bethesda (MD): National Library of Medicine (US). 2000 Feb 29 \u2010. Identifier NCT04246684 Short RT Versus RCT Followed by Chemo.and Organ Preservation for Interm and High\u2010risk Rectal Cancer Patients; 2023 Nov 29 [cited 2024 Aug 9]; Available from:https:\/\/clinicaltrials.gov\/study\/NCT04246684."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.043802"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5896"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005799"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002197"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-023-04573-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2022.01221.0174"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2023.05.031"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.3258"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172889"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.28001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:37:57Z","timestamp":1763224677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.28001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jso.28001"],"URL":"https:\/\/doi.org\/10.1002\/jso.28001","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"2024-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}