{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:09:11Z","timestamp":1788541751195,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neoadjuvant chemotherapy (NC) for early pancreatic ductal adenocarcinoma (PDAC) remains controversial. We investigate the adoption of NC and its impact on survival in clinical T1 (cT1) PDAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>National Cancer Database (2006\u20132017) was reviewed for cT1 PDAC. Patients receiving NC and surgery were compared with patients undergoing upfront surgery (US).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 5886 patients were included. NC use increased from 4.8% in 2006 to 18.8% in 2017. The NC group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009618) versus the US group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095268) had: younger age (66 years vs. 68 years), smaller tumor size (2\u2009cm vs. 2.2\u2009cm), more pancreas head tumors (77% vs. 70.6%), lower lymph\u2010vascular invasion (25.9% vs. 40.6%), and less lymph node positivity (43.6% vs. 54.5%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. Factors associated with receipt of NC were: younger age, recent year of diagnosis, and treatment at an academic program. In the NC group versus the US group, median OS was 35.2 months versus 28.3 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. Factors associated with improved survival included: well differentiated pathology, R0 surgical margins, and receipt of chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In cT1 PDAC, chemotherapy is associated with improved survival. In a surgery\u2010first approach, only 59% of patients receive adjuvant chemotherapy. These data suggest consideration of neoadjuvant therapy for early pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.28003","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T23:44:32Z","timestamp":1731627872000},"page":"646-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trends and Outcomes of Neoadjuvant Chemotherapy for Clinical Stage T1 Pancreatic Cancer"],"prefix":"10.1002","volume":"131","author":[{"given":"Shruti","family":"Koti","sequence":"first","affiliation":[{"name":"Department of Surgery Northwell Health New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Standring","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwell Health New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan","family":"Vithlani","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwell Health New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-0124","authenticated-orcid":false,"given":"Danielle","family":"Deperalta","sequence":"additional","affiliation":[{"name":"Department of Surgery Northwell Health New Hyde Park New York USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Surgery NYU Langone Hospital\u2010Long Island Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Karpeh","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Division of Surgery Northwell Health Cancer Institute New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Weiss","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Division of Surgery Northwell Health Cancer Institute New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Lad","sequence":"additional","affiliation":[{"name":"Department of Surgery Icahn School of Medicine at Mount Sinai Manhattan New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00328"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01366-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113430"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9384-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00405-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.07.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11141-5"},{"key":"e_1_2_8_11_1","unstructured":"\u201cTesting the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer\u201d(NCT04340141).Secondary \u201cTesting the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer\u201d (NCT04340141) https:\/\/clinicaltrials.gov\/study\/NCT04340141."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040873"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.06.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02233"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-015-2890-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-014-0737-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2319"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005830"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27357"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30843"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znad373"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2022.100939"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v14.i10.1903"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.03.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184627"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac354"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.28003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:37:51Z","timestamp":1763224671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.28003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jso.28003"],"URL":"https:\/\/doi.org\/10.1002\/jso.28003","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}