{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:44:54Z","timestamp":1773110694002,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Due to heterogeneous characteristics of primary cancers, the efficacy of pulmonary metastasectomy (PM) in nonprimary lung cancers has not been investigated. This study aims to investigate the clinical outcomes of PM for non\u2010primary lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search for meta\u2010analyses on PM for nonprimary lung cancers was conducted, encompassing publications up to January 3, 2024. This included seven primary cancers: renal cell, breast, adrenocortical, head and neck cancers, melanoma, germ cell tumors, and sarcoma. Overall survival and recurrence rates post\u2010PM were assessed using random\u2010effect models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 16 systematic\u2010review articles and 101 individual studies, involving 10\u2009277 patients who underwent PM for nonprimary lung cancer. About half of the patients (47.1%) presented with multiple metastasis, and complete resection achieved in 87.2% [95% CI: 83.0\u201390.8]. The pooled 5\u2010year overall survival rate post\u2010PM was 41.2% [95%CI: 37.1%\u201345.4%]. Patients with germ cell tumors demonstrated higher survival rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while melanoma exhibited the worst outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). During follow\u2010up, 57.6% [95% CI: 46.4\u201368.1] had recurrence; 48% of them had intrathoracic\u2010only recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study underscores the survival benefits associated with PM. Overall survival rates following PM did not differ based on primary cancer types. These findings highlight the importance of recognizing and incorporating PM into clinical practice when appropriate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.28033","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T10:25:15Z","timestamp":1734258315000},"page":"1035-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Pulmonary Metastasectomy for Non\u2010Primary Lung Cancer: Umbrella Review of Meta\u2010Analyses"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-4470","authenticated-orcid":false,"given":"Wongi","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Dignity Health St. Joseph Medical Center Stockton Stockton California 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