{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:12:08Z","timestamp":1791285128303,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Anastomotic leak (AL) is a serious complication following esophagectomy and is often linked to poor perfusion of the gastric conduit (GC) and esophageal stump (EC). The aim of this study is to compare the efficacy of intraoperative Indocyanine green fluorescence angiography (ICG\u2010FA) versus visual assessment VA) to assess perfusion status and its impact on the rate of AL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight esophageal or gastroesophageal junction carcinoma patients were randomized to ICG\u2010FA (28) and VA (30) groups. Perfusion status was assessed with VA alone in the VA group and with VA followed by ICG\u2010FA in the ICG\u2010FA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ICG\u2010FA group had a lower leak rate of 4% when compared to 27% in the VA group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). ICG\u2010FA identified nine cases where VA misjudged the GC tip vascularity, thereby avoiding unnecessary resections. ICG\u2010FA necessitated revision of the GC tip in one case missed by VA and also identified poor perfusion of ES tip in three cases mandating revision which were deemed well\u2010perfused by VA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICG\u2010FA demonstrated superiority over VA in assessing perfusion adequacy of the GC and ES, which resulted in a statistically significant decrease in the rate of anastomotic leaks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.28145","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:34:52Z","timestamp":1747204492000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Indocyanine Green Fluorescence Angiography Versus Visual Assessment for Assessing Perfusion of Gastric Conduit and Esophageal Stump in Post Esophagectomy Patients: A Pilot Randomized Controlled Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-6200","authenticated-orcid":false,"given":"Subramanyeshwar Rao","family":"Thammineedi","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Basavatarakam Indo American Cancer Hospital and Research Institute Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujit Chyau","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Basavatarakam Indo American Cancer Hospital and Research Institute Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Basavatarakam Indo American Cancer Hospital and Research Institute Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajesh 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