{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:27:29Z","timestamp":1781886449792,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemicortical allograft reconstruction is associated with low short\u2010term complication rates and excellent functional outcomes. However, data on their long\u2010term complication profile and patient\u2010reported outcomes is scarce to non\u2010existent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with hemicortical resection and allograft reconstruction for primary bone tumors were included. The Henderson classification for biologic reconstruction was used to classify allograft failures. Functional outcomes at a minimum of 10 years postoperatively were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients with femur hemicortical allograft and 20 with tibia allograft were included. Allograft failure and reoperation occurred in 39% and 52% of patients, respectively. The main causes of allograft failure were infection, soft\u2010tissue failure, and structural failure (9% each). Tibia allografts had a higher rate of failure due to infection (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and nonunion (<jats:italic>p<\/jats:italic>\u2009=\u20090.049) compared to femur allografts. There were no differences in allograft failure\u2010free survival based on bone (tibia vs. femur) and osteosynthesis type (plate vs. screw and plates). Median TESS\u2010LE and LEFS scores were 98.8% and 87.5% for tibia allografts, and 98.1% and 97.5% for femur allografts, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term allograft failure\u2010free survival was excellent, with infection and soft\u2010tissue failures as the main failure mechanisms. At last follow\u2010up, patients who still had the hemicortical allograft displayed excellent functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level IV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.28147","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:49:04Z","timestamp":1747126144000},"page":"1670-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["What Are the Long\u2010Term Clinical and Functional Outcomes After Hemicortical Allograft Reconstruction for Primary Bone Tumors?"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-6362","authenticated-orcid":false,"given":"Marcos R.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Okay","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph O.","family":"Werenski","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Newman","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Raskin","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-9004","authenticated-orcid":false,"given":"Santiago A.","family":"Lozano\u2010Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4065846"},{"key":"e_1_2_8_3_1","first-page":"649","article-title":"Limb Salvage Compared With Amputation for Osteosarcoma of the Distal End of the Femur: A Long\u2010Term Oncological, Functional, and Quality\u2010of\u2010Life Study","volume":"76","author":"Rougraff B. 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