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Statistically significant decreases in urine volume, sodium excretion, and PAH clearance, and increases in urinary potassium and the plasma glucose were observed concomitantly. The exact reason for these alterations in renal function remains undefined, but it would appear to be a tubular effect and may be related to inhibition of RNA synthesis with secondary inhibition of synthesis of various enzymes involved in tubular transport.<\/jats:p>","DOI":"10.1002\/jso.2930020202","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:38:52Z","timestamp":1171935532000},"page":"89-96","source":"Crossref","is-referenced-by-count":1,"title":["Influence of mithramycin on RNA synthesis and renal function in the canine kidney\u2014a trial study"],"prefix":"10.1002","volume":"2","author":[{"given":"R. B.","family":"Gilsdorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Cancer Res."},{"key":"e_1_2_1_12_1","first-page":"143","article-title":"Mithramycin: An antibiotic with antitumor properties","volume":"3","author":"Roa K. V.","year":"1960","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"e_1_2_1_13_1","first-page":"200","volume-title":"Principles of Renal Physiology","author":"Smith H. W.","year":"1956"},{"key":"e_1_2_1_14_1","first-page":"70","article-title":"Mithramycin inhibitors of RNA synthesis in mouse ascites tumor","volume":"6","author":"Yarbro J. W.","year":"1965","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"e_1_2_1_15_1","first-page":"36","article-title":"Mithramycin inhibition of ribonucleic acid synthesis","volume":"26","author":"Yarbro J. W.","year":"1966","journal-title":"Cancer Res."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930020202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930020202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:37:19Z","timestamp":1699850239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930020202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,1]]}},"alternative-id":["10.1002\/jso.2930020202"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930020202","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,1]]}}}