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Since these diseases are apparently not epidemic in nature, immunization\u2014which has been so successfully applied for control of many viral illnesses\u2014will probably be less useful. The development of effective, broad\u2010spectrum, antiviral compounds is therefore imperative. Developing drugs with dart\u2010like specificity demands a clear knowledge of the differences in virus and cell replicative mechanisms. Specificity for viral processes is essential if cell toxicity is to be circumvented, since cirus replication occurs intracellularly with a partial dependence on cell macromolecular functions. With an increasing knowledge of the growth cycle of viruses, we recognize that both cytolytic and oncogenic viruses\u2014although causing antithetic effects on cells\u2014may have common biochemical mechanisms for assembling viral proteins and nucleic acids. There similarities suggest it is possible to approach therapeutically these two types of viral infection in similar ways. Specific antiviral drugs should be useful, not only in a prophylactic way, but also as an additional mode of therapy which can complement the surgical and chemotherapeutic approach to patients with established tumors.<\/jats:p>","DOI":"10.1002\/jso.2930050207","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T02:18:05Z","timestamp":1171937885000},"page":"113-136","source":"Crossref","is-referenced-by-count":3,"title":["Chemotherapy of human oncogenic viral infections: The possible role of interferon and reverse transcriptase inhibitors"],"prefix":"10.1002","volume":"5","author":[{"given":"William A.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.5.920"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4010.704"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/235032a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/2261209a0"},{"key":"e_1_2_1_6_1","first-page":"12","article-title":"The role of interferon during viremia","volume":"96","author":"Baron S.","year":"1966","journal-title":"I. 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