{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:40:09Z","timestamp":1699836009706},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":12252,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1973,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spontaneously observed and exogenously induced renal tumors in mice and rats have been described. Occasionally occurring tumors in other species have been reviewed. The relationships between the spontaneously observed and induced tumors and endocrine factors are reviewed. Practical applications for the use of induced tumors as screening techniques for chemotherapy of advanced renal cancer in man are discussed. Limitations in the present models are apparent. Both hormonal and nonhormonal environments can effect relative growth rates in several species of the induced tumors. Common metabolic pathways in several of the alkylating agents for the inductions of renal tumors are described. The virus relationships to frog tumors have been appreciated for some time and have been further studied. Present clinical problems and controversies, however, remain. Important areas for further study of these models can provide helpful clinical information and have been discussed.<\/jats:p>","DOI":"10.1002\/jso.2930050511","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T02:10:42Z","timestamp":1171937442000},"page":"509-516","source":"Crossref","is-referenced-by-count":2,"title":["Experimental aspects of renal tumors"],"prefix":"10.1002","volume":"5","author":[{"given":"Harry","family":"Grabstald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"36","article-title":"Differences between the surface properties of normal and tumor cells","volume":"16","author":"Ambrose E. J.","year":"1960","journal-title":"Acta. Un. Int. 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