{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:10:34Z","timestamp":1699830634197},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":11887,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has now become abundantly clear that in recent years a multiplicity of chemical, physical, and other agents to which man is exposed are capable of damaging his chromosomes. The effects of these agents on the human somatic and possibly germ cells have now been well documented, although not without some controversy over the interpretation and implications of the data. While biological and clinical significance of chromosomal aberrations are not as yet well understood, recent epidemiological evidence, from mutagen\u2010exposed human populations, and recent experiments on viral\u2010induced transformation of chromosomally abnormal cells, suggest an association between chromosome aberrations and oncogenesis.<\/jats:p>","DOI":"10.1002\/jso.2930060211","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T02:08:50Z","timestamp":1171937330000},"page":"163-181","source":"Crossref","is-referenced-by-count":0,"title":["Chromosomes and cancer"],"prefix":"10.1002","volume":"6","author":[{"given":"N. P.","family":"Bishun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Raven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"539","article-title":"Chromosome abnormalities as primary events in human malignant disease. Evidence frommarker chromosomes","volume":"36","author":"Atkin N. B.","year":"1966","journal-title":"J. Nat. Cancer Inst."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5795.271"},{"key":"e_1_2_1_4_1","first-page":"301","volume-title":"Biologie et Physiologie Cellulaire","author":"Berkaloff A.","year":"1967"},{"key":"e_1_2_1_5_1","volume-title":"Modern Trends in Onocology","author":"Bishun N. P.","year":"1973"},{"key":"e_1_2_1_6_1","unstructured":"Bishun N. P.(1970). Personal observation."},{"key":"e_1_2_1_7_1","first-page":"289","volume-title":"Action inhibitrico du virus de la rub\u00e9ole sur la multiplication de differentea cellules embryonnaires humaines cultiv\u00e9es in vitro","author":"Bou\u00e9 A.","year":"1964"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Bou\u00e9 A. Plotkin S. A. andBou\u00e9 J. G.(1965).Action du virus de la rub\u00e9ole sur differente systemes de culture dc cellules embryonnaires liumaines. Arch. ges. Virusf 16\u2013413.","DOI":"10.1007\/BF01253853"},{"key":"e_1_2_1_9_1","first-page":"687","article-title":"Alterations chromosomiques induites par le virus de la rubiole dans les cellulcs embyronnaires diploides humaines cultiv\u00e9esin vitro","volume":"259","author":"Bou\u00e9 J. G.","year":"1964","journal-title":"C. R. Acad. Sci., Paris"},{"key":"e_1_2_1_10_1","first-page":"997","article-title":"Alterations chromosomiqucs induites par le virus de la rub\u00e9ole et par le virus de la rougeole dans les cellules diploides humaines cultiv\u00e9esin vitro","volume":"15","author":"Bou\u00e9 J. G.","year":"1967","journal-title":"Path. Biol."},{"key":"e_1_2_1_11_1","first-page":"178","article-title":"Evolution chromosomiques d'un clone de cellulec humaines transformies par le virus du sarcomede rous","volume":"266","author":"Bou\u00e9 J. G.","year":"1968","journal-title":"C. R. Acad. Sci., Paris"},{"key":"e_1_2_1_12_1","first-page":"1929","volume-title":"Origin of Malignant Tumours","author":"Boveri T.","year":"1914"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/2191072a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910090206"},{"key":"e_1_2_1_15_1","first-page":"550","article-title":"Mutagenic selectivity for the RNA\u2010forming genes in relation to the carcinogenicity of the alkylating agents andpolycyclic aromatics","volume":"32","author":"Falimy O. G.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-677950-9.50016-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)91893-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030650110"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5312.1097"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","unstructured":"Henle W. Dienl V. Kohn G. Zur Hausen H. andHenle G.(1967).Herpes\u2010type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science157\u20131064.","DOI":"10.1126\/science.157.3792.1064"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb48286.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a106296"},{"key":"e_1_2_1_23_1","first-page":"207","article-title":"Some effects of abnormal toxicity on dividing cells in chicktissue cultures","volume":"93","author":"Hughes A.","year":"1952","journal-title":"Quart. J. Micros. Sci."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-0463.1957.tb00003.x","article-title":"The chromosomes of two highlymalignant tumours","volume":"40","author":"Ising U.","year":"1957","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"e_1_2_1_25_1","first-page":"1","article-title":"Uber das Verhalter Der Chromosomen in Den Somatichen, Zellen, des Meuchen","volume":"16","author":"Kemp J.","year":"1949","journal-title":"Zts. Mikr. Anat. Forsch"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood.V26.5.610.610","article-title":"Chromosomal aberrations inacute leukemia","volume":"26","author":"Kiossoglou K. A.","year":"1965","journal-title":"Blood."},{"key":"e_1_2_1_27_1","volume-title":"The Mutagenicity of Pesticides: Concepts and Evaluations","author":"Lederberg J.","year":"1971"},{"key":"e_1_2_1_28_1","first-page":"569","volume-title":"Environmental Chemical Mutagens","author":"Legator M. S.","year":"1970"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.23.020172.002213"},{"key":"e_1_2_1_30_1","first-page":"210","volume-title":"Les Chromosomes Humaines","author":"LeJeune J.","year":"1965"},{"key":"e_1_2_1_31_1","first-page":"41","article-title":"Le mongolisme, premier la example d'aberrationautosomique humaine","volume":"1","author":"LeJeune J.","year":"1959","journal-title":"Ann. Genet."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1966.tb02032.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1601-5223.1967.tb02117.x","article-title":"Some current problems ofcancer cytogenetics","volume":"57","journal-title":"Hereditas"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/oxfordjournals.bmb.a070535","article-title":"Recent advances in the study ofviral oncogenesis","volume":"23","author":"MacPherson I.","year":"1967","journal-title":"Brit. Med. Bull."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3758.80"},{"key":"e_1_2_1_35_1","volume-title":"Environmental Chemical Mutagens","author":"Miller E. C.","year":"1970"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","unstructured":"Montgomery J. R. South M. A. Rawls W. E. Melnick J. L. Olson G. B. Dent P. B. andGood R. A.(1967).Viral inhibition of lymphocyte response to phytohaemagglutinin. Science157\u20131068.","DOI":"10.1126\/science.157.3792.1068"},{"key":"e_1_2_1_37_1","first-page":"109","article-title":"Pathogenesis ofcongenital rubella","volume":"16","author":"Naeye R. L.","year":"1965","journal-title":"JAMA"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1964.tb01943.x"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1965.tb02008.x"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1962.tb01820.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196706222762505"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(69)90020-3"},{"key":"e_1_2_1_43_1","first-page":"705","article-title":"Rubella virus carrier cultures derived from congenitallyinfected infants","volume":"75","author":"Rawls W. E.","year":"1965","journal-title":"J. Exp. Med."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196707)20:7<1099::AID-CNCR2820200713>3.0.CO;2-R"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00393791"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.48.7.1164"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/233555a0"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)90642-2"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80204-4"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(67)90007-2"},{"key":"e_1_2_1_51_1","unstructured":"W. H. O.Scientific Report. (1971).Evaluation and Testing of Drugs for Mutagenicity: Principles and Problems. No. 482 Geneva."},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372971"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930060211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930060211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:49:29Z","timestamp":1699829369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930060211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1002\/jso.2930060211"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930060211","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}