{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:10:38Z","timestamp":1699830638147},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":11887,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Normothermic extracorporeal oxygenation and oxygen\u2010hemoglobin dissociation characteristics of stroma\u2010free hemoglobin solution (SFHS) were studied. One hour of normothermic cardiopulmonary bypass, using a total SFHS prime, resulted in arterial pH 7.31 \u2013 7.38, PaO<jats:sub>2<\/jats:sub> 120 \u2013 140 mm Hg, SaO<jats:sub>2<\/jats:sub> 99%, and mean arterial pressure of 85 mm Hg. One hour after perfusion, the animal died with acute pulmonary edema from severe hemodilution and hypoxemia. Hypothermic (25\u00b0C) myocardial metabolism was studied. Myocardial utilization (MU) values for oxygen, lactate, pyruvate, and glucose during SFHS perfusion were 1.46 and 1.71 m1\/100 gm\/min, +1.01 and +0.08 mg\/100 gm\/min, \u22120.32 and \u22120.04 mg\/100 gm\/min, and \u221234.4 and \u22129.50 mg\/100 gm\/min. MU values during whole blood perfusion were 2.21 and 2.13 m1\/100 gm\/min, \u22125.19 and \u22122.99 mg\/100 gm\/min, \u22120.65 and 0.22 mg\/100 gm\/min, and \u221213.7 and \u22125.32 mg\/100 gm\/min. These data suggest the necessity of further studies to identify any usefulness of SFHS as a whole blood substitute.<\/jats:p>","DOI":"10.1002\/jso.2930060509","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T02:52:13Z","timestamp":1171939933000},"page":"451-459","source":"Crossref","is-referenced-by-count":2,"title":["Experimental use of heterologous stroma\u2010free hemoglobin solution (SFHS) as a whole blood substitute"],"prefix":"10.1002","volume":"6","author":[{"suffix":"jr.","given":"Wilfred F.","family":"Holdefer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund A.","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.2.526"},{"key":"e_1_2_1_3_1","first-page":"19","article-title":"Immunogenic properties of stroma vs. stroma\u2010free hemoglobin","volume":"28","author":"Cochin A.","year":"1972","journal-title":"Surg. Forum"},{"key":"e_1_2_1_4_1","first-page":"202","article-title":"Successful orthotopic transplantation of canine hearts after in vitro preservation for 24 to 28 hours","volume":"28","author":"Copeland J. G.","year":"1972","journal-title":"Surg. Forum"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(67)90028-X"},{"key":"e_1_2_1_6_1","first-page":"198","article-title":"Stroma\u2010free hemoglobin. 1. Preparation and observations on in vitro changesin coagulation","volume":"74","author":"Moss G. S.","year":"1973","journal-title":"Surg."},{"key":"e_1_2_1_7_1","first-page":"185","article-title":"Stroma\u2010free hemoglobin solution: The \u201cideal\u201d blood substitute?","volume":"66","author":"Peskin G. W.","year":"1969","journal-title":"Surg."},{"key":"e_1_2_1_8_1","volume-title":"Quantitative Clinical Chemistry","author":"Peters J. P.","year":"1932"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3913.1643"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.126.6.1127"},{"key":"e_1_2_1_11_1","first-page":"395","article-title":"Effects of stroma\u2010free hemoglobin solution on clearance rate andrenal function","volume":"71","author":"Relihan M.","year":"1972","journal-title":"Surg."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.33.1.154"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35464"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930060509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930060509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:50:00Z","timestamp":1699829400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930060509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1002\/jso.2930060509"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930060509","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}