{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:40:25Z","timestamp":1699850425410},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":11157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erythropoietin (ESF) levels were assayed in rats bearing the Wistar\u2010Furth Wilms' transplantable tumor. Sites of tumor inoculation varied from subcutaneous, intramuscular, intrarenal (subcapsular), to intra\u2010peritoneal. Two\u2010thirds of the animals exhibited ESF elevations without polycythemia, or severe anemia (HCT &lt; 30.0 vol %). The elevations in ESF were not detectably related to the time of sacrifice (age of the animal), size of the primary tumor, or number of gross metastatic foci. The diminished ESF response noted to animals given intramuscular tumor implantations is believed to reflect differences in tumor blood and lymphatic supply at the various sites of inoculation. The pattern of ESF responses in the Wistar\u2010Furth Wilms' tumor model is thus quite similar to that which we have observed in man, and appears to represent an animal model for tumor\u2010related ectopic hormone release. The nature of the hormone is believed to differ from that seen in normal physiological states.<\/jats:p>","DOI":"10.1002\/jso.2930080207","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T04:29:26Z","timestamp":1171945766000},"page":"131-135","source":"Crossref","is-referenced-by-count":5,"title":["Erythropoietin levels in wistar\u2010furth Wilms' tumor rats"],"prefix":"10.1002","volume":"8","author":[{"given":"Gerald P.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis D.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin A.","family":"Mirand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"487","article-title":"Erythropoietin levels in patients with Wilms' tumor. Follow\u2010up evaluation","volume":"72","author":"Murphy G. P.","year":"1972","journal-title":"N. Y. State J. Med."},{"key":"e_1_2_1_3_2","first-page":"617","article-title":"Erythropoietin release from renal cell carcinomas grown in tissue culture","volume":"1","author":"Murphy G. P.","year":"1970","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197007)26:1<191::AID-CNCR2820260124>3.0.CO;2-S"},{"key":"e_1_2_1_5_2","first-page":"26","article-title":"Erythropoietin release associated with Wilms' tumor","volume":"120","author":"Murphy G. P.","year":"1967","journal-title":"Johns Hopkins Med. J."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)59451-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","unstructured":"Murphy G. P. andWilliams P. D.(1975b).The effects of chemotherapy on the Wistar\u2010Furth Wilms' tumors. J. Med. (In press).","DOI":"10.1016\/0090-4295(75)90343-X"},{"key":"e_1_2_1_8_2","first-page":"320","article-title":"Characterization of a Wilms' tumor model","volume":"12","author":"Saroff J.","year":"1975","journal-title":"Invest. Urol."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930080207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930080207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:08:16Z","timestamp":1699848496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930080207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1002\/jso.2930080207"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930080207","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}