{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:34:59Z","timestamp":1699922099779},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":10791,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two hundred and one cases of premenopausal women with breast cancer who underwent prophylactic castration with subsequent recurrence were reviewed to ascertain the degree of responsiveness of these patients to subsequent endocrine manipulation. We show that the standard endocrine manipulations, particularly the major ablations, retain a fair degree of activity in this group. There is a suggestion that the longer the castration\u2010recurrence interval, the higher the chance of a response, but the difference is significant only for osseous\u2010dominant disease. As in other patient groups, responders to subsequent endocrine manipulations live longer than nonresponders.<\/jats:p>","DOI":"10.1002\/jso.2930090107","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T03:22:21Z","timestamp":1171941741000},"page":"39-43","source":"Crossref","is-referenced-by-count":0,"title":["Responsiveness to endocrine manipulations in breast cancer after \u201cprophylactic\u201d castration"],"prefix":"10.1002","volume":"9","author":[{"given":"Richard","family":"Kaufman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Wittes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"141","volume-title":"Endocrine Therapy of Malignant Disease","author":"Stoll B.","year":"1972"},{"key":"e_1_2_1_3_2","first-page":"215","article-title":"Endocrine ablation in disseminated mammary carcinoma","volume":"115","author":"McDonald I.","year":"1962","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(69)90012-9"},{"key":"e_1_2_1_5_2","first-page":"1055","article-title":"Results of a clinical trial concerning the worth of prophylactic oophorectomy for breast cancer","volume":"131","author":"Ravdin R. G.","year":"1970","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_1_6_2","volume-title":"Estrogen Receptors in Human Breast Cancer","author":"McGuire W. L.","year":"1975"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060380037009"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5351.210"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.63040090001009"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930090107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930090107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:57:44Z","timestamp":1699851464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930090107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1002\/jso.2930090107"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930090107","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}