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In contrast, 4 of 6 animals that had hepatic artery ligation and chemotherapy infusion, and 3 of 6 that had ligation of the hepatic artery only, died during the same period of follow\u2010up. Progressive liver damage after dearterialization accounted for the high mortality rate. Histologic examination of liver biopsies taken from animals in these latter groups revealed marked destruction of the parenchyma. These changes were more extensive in animals treated by a combination of hepatic artery ligation and chemotherapy infusion. To avoid the injurious effects of permanent interruption of the hepatic arterial flow on normal liver tissue an alternative method of hepatic dearterialization is currently under investigation.<\/jats:p>","DOI":"10.1002\/jso.2930110108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T04:47:24Z","timestamp":1171946844000},"page":"39-44","source":"Crossref","is-referenced-by-count":1,"title":["Effect of infusion chemotherapy and hepatic artery ligation on normal liver: Experimental study in the cat"],"prefix":"10.1002","volume":"11","author":[{"given":"Sam","family":"Delk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"El\u2010Domeiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90155-9"},{"key":"e_1_2_1_3_1","first-page":"170","article-title":"Intrahepatic arterial infusion with 5\u2010Fluorouracil","volume":"71","author":"Ansfield FJ","year":"1972","journal-title":"Wis Med J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90161-5"},{"key":"e_1_2_1_5_1","first-page":"772","article-title":"Safe hepatic artery occlusion in dogs","volume":"66","author":"Conolly WB","year":"1969","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197101)27:1<7::AID-CNCR2820270103>3.0.CO;2-Q"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1972.04180080132022"},{"key":"e_1_2_1_8_1","first-page":"131","article-title":"Studies in liver circulation, ligations of liver arteries or gall ducts of guinea pigs","volume":"21","author":"Hailer CV","year":"1974","journal-title":"Acta Hepatogastroenterol"},{"key":"e_1_2_1_9_1","first-page":"167","article-title":"Effect of ligation of the hepatic artery on drug metabolism by liver microsomal enzymes","volume":"61","author":"Kaltila EH","year":"1972","journal-title":"Ann Chir Gynaecol Fenn"},{"key":"e_1_2_1_10_1","first-page":"160","article-title":"Liver histological and histochemical changes after hepatic artery ligation in rats","volume":"61","author":"Kaltiala EH","year":"1972","journal-title":"Ann Chir Gynaecol Fenn"},{"key":"e_1_2_1_11_1","first-page":"225","article-title":"Survival of dogs treated with hyperbaric oxygen following hepatic artery lieation","volume":"59","author":"Karasewich EG","year":"1966","journal-title":"Surgery"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1974.tb05700.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90093-6"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(73)90147-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1074::AID-CNCR2820350409>3.0.CO;2-T"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930110108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930110108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:57:48Z","timestamp":1699851468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930110108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/jso.2930110108"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930110108","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}