{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T19:10:52Z","timestamp":1766603452449},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":10061,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A therapeutic dose of <jats:sup>131<\/jats:sup>I was given to a 53\u2010year\u2010old man with thyrotoxicosis three and one\u2010half hours prior to death. The distribution of <jats:sup>131<\/jats:sup>I in the thyroid gland was studied by autoradiography, and the radioactivity in various fresh tissues was measured. Radioactivity was distributed evenly throughout the colloid;small amounts were present in follicular cells. Radioactivity was not localized to the periphery of colloid follicles as observed in an earlier report. Papillary projections were associated with increased radioactivity. Decreased ratioactivity was associated with oxyphilic cells. Measurement of <jats:sup>131<\/jats:sup>I in individual tissues showed that per gram of tissue the thyroid gland contained approximately 50 times that of intestine and spleen and approximately 100 times that of liver and bone.<\/jats:p>","DOI":"10.1002\/jso.2930110402","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T04:56:25Z","timestamp":1171947385000},"page":"283-288","source":"Crossref","is-referenced-by-count":1,"title":["Early tissue distribution of therapeutic <sup>131<\/sup>I in a patient with thyrotoxicosis"],"prefix":"10.1002","volume":"11","author":[{"given":"E.","family":"Vachal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wegst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0900205"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-43-5-306"},{"key":"e_1_2_1_4_2","first-page":"505","article-title":"Autoradiographische Untersuchungen des menschlichen intrathyroidalen Jodstoffwechsels","volume":"208","author":"Schmidt HJ","year":"1963","journal-title":"Deutsch Arch Klin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-56-1-9"},{"key":"e_1_2_1_6_2","first-page":"50","volume-title":"Thyroid","author":"Nadler NJ","year":"1974"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-70-2-278"},{"key":"e_1_2_1_8_2","first-page":"98","volume-title":"Studies on dosage in cancer therapy. Brookhaven Conference Report on Radioiodine. Brookhaven National Laboratory","author":"Marinelli LD","year":"1948"},{"key":"e_1_2_1_9_2","first-page":"1379","article-title":"The distribution of radioiodine in a patient with metastatic adenocarcinoma of the thyroid","volume":"19","author":"Ball JE","year":"1949","journal-title":"J Clin Endocrino"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-10-9-1007"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-11-8-843"},{"key":"e_1_2_1_12_2","first-page":"288","volume-title":"Principles of Radioisotope Methodology","author":"Chase GD","year":"1967"},{"key":"e_1_2_1_13_2","first-page":"18","volume-title":"Tumors of the Thyroid Gland,","author":"Meissner WA","year":"1968"},{"key":"e_1_2_1_14_2","first-page":"29","article-title":"Evaluation of the normal range of values for uptake of radioactive iodine by the thyroid gland","volume":"715","author":"Schober B","year":"1976","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0021-9258(17)41130-6","article-title":"Distribution of a large dose of thyroxine labeled with radioiodine in the organs and tissues of the rat","volume":"171","author":"Gross J","year":"1947","journal-title":"J Biol Chem"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930110402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930110402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:55:55Z","timestamp":1699844155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930110402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/jso.2930110402"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930110402","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}