{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:20:43Z","timestamp":1756995643286},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":10061,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Normal family members of eight diagnosed patients suffering from alpha\u2010chain disease had been investigated by immunoelectrophoresis for abnormal alpha\u2010chain protein in their serum. The pattern was demonstrated in four families only, of different members, but all are of the first\u2010degree relationship. The aim of the study was to determine any possible hereditary defect of the immune system in such patients, as compared to the immune system of the normal members of the family who had abnormal protein in their serum. It was found that in both patients and normal members, the proportion of circulating B\u2010lymphocytes was much higher than normal, whereas that of T\u2010lymphocytes was lower than normal. Neither could be sensitized to DNCB, and their skin tests to tuberculin were negative. From all these findings, it was concluded that the disease was a B\u2010cell disease of IgA type transmitted by a hereditary factor associated with a low level of cellular immunity. Further studies are required to support this hypothesis.<\/jats:p>","DOI":"10.1002\/jso.2930110412","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T04:56:25Z","timestamp":1171947385000},"page":"365-374","source":"Crossref","is-referenced-by-count":6,"title":["Lymphocytes subpopulation in normal family members of patients with alpha\u2010chain disease"],"prefix":"10.1002","volume":"11","author":[{"given":"ELIAS A. K.","family":"Alsabti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Safo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225258"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90009-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.109.5.1131","volume":"109","author":"Buxbaum JN","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.12.947"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/224597a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.207"},{"key":"e_1_2_1_8_1","first-page":"124","volume":"26","author":"Kharazmi A","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1978.7"},{"key":"e_1_2_1_10_1","first-page":"235","volume":"2","author":"Mancini G","year":"1965","journal-title":"Br J Cancer"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.11.8.673"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.132.5.1001"},{"key":"e_1_2_1_13_1","first-page":"104","volume-title":"In Vitro Methods incell Mediated Immunity,","author":"Preud'Homme JL","year":"1976"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3860.1396"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb13558.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106204"},{"key":"e_1_2_1_17_1","first-page":"127","volume-title":"Proceedings of 8th Leukocyte Culture Conference","author":"Smith RW","year":"1974"},{"key":"e_1_2_1_18_1","first-page":"442","volume":"21","author":"Strong DM","year":"1975","journal-title":"Clin Exp Immunol"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930110412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930110412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:56:04Z","timestamp":1699844164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930110412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/jso.2930110412"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930110412","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}