{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:28:34Z","timestamp":1700717314215},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":10061,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A retrospective study of 1, 178 females suffering from cancer of the breast and treated by radical mastectomy is presented. All operations were performed by essentially one group of four senior surgeons, each either trained or connected with Memorial Sloan Kettering Hospital in New York and spent practically all of his professional career in the treatment of cancer. The same techniques of surgery were practiced. The same principles of the overall treatment were utilized; namely, if there were no metastases to lymph nodes detected on histologic studies, no radiation therapy was given. If metastases were present in the axillary lymph nodes, each of the patients received postoperative radiation therapy. None received either chemotherapy nor immunotherapy, as primary treatment. The study includes all patients treated between 1930 and 1965 and complete follow\u2010up data were obtained in 94.6% of all patients. Five hundred and ninety\u2010six patients were classified histologically as Stage I (50.6%), 291 as Stage II (24.7%), 74 as Stage III (6.3%), and 217 patients (18.4%) were undetermined. The total number of patients who developed a second primary cancer in the remaining breast was 91 (7.7%), and only 51 patients (4.3%) developed local recurrences in the chest wall or axilla. The mean age of the patients was 51.9 years. The absolute 5\u2010year survival of all patients was 64% and the 10\u2010year survival equaled 54.6%. The 9.4% mortality between the 5\u2010 and 10\u2010year survival emphasizes that the 10\u2010year survival figures are a more accurate index of survival. The larger the tumor, usually the poorer the prognosis, except where the tumor was 8 cm or larger where the prognosis was rather good. This indicates some biologic resistance.<\/jats:p>","DOI":"10.1002\/jso.2930120208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T06:44:32Z","timestamp":1171953872000},"page":"137-153","source":"Crossref","is-referenced-by-count":16,"title":["Results of treating 1, 178 patients with breast cancer by radical mastectomy and postoperative irradiation where metastases to axillary lymph nodes occurred"],"prefix":"10.1002","volume":"12","author":[{"given":"Irving M.","family":"Ariel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1311","article-title":"Factors influencing short and long term survival of breast cancer patients","volume":"122","author":"Berg JW","year":"1966","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5299.213"},{"key":"e_1_2_1_4_1","unstructured":"BonadonnaG RossiA ValagussaP BanfiA VeronesiU(1976):The CMF program for operable breast cancer with positive axillary nodes. Presented at the Symposium on Breast Cancer: A Report to the Profession 1976. Washington November 22\u201323."},{"key":"e_1_2_1_5_1","volume-title":"New York Cancer Society Meeting","author":"Cutler SJ","year":"1966"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197503)35:3<714::AID-CNCR2820350326>3.0.CO;2-V"},{"key":"e_1_2_1_7_1","first-page":"491","article-title":"Lobular carcinoma in situ: A rare form of mammary cancer","volume":"17","author":"Foote FW","year":"1941","journal-title":"Am J Pathol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196109000-00009"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196104000-00002"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1931.01160070088006"},{"key":"e_1_2_1_11_1","first-page":"126","volume-title":"Diagnosis and Treatment of Breast Lesions","author":"Leis HP","year":"1970"},{"key":"e_1_2_1_12_1","first-page":"1","article-title":"The surgeon's dilemma in breast cancer","volume":"1","author":"Leis HP","year":"1975","journal-title":"Breast"},{"key":"e_1_2_1_13_1","first-page":"527","article-title":"Breast cancer in the ninth and tenth decades","volume":"12","author":"Leis HP","year":"1964","journal-title":"J Am Ber Soc"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.02940270011003"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/jama.1966.03100050096033","article-title":"Breast carcinoma in children","volume":"195","author":"McDivitt RW","year":"1966","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2242(57)80020-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195305000-00012"},{"key":"e_1_2_1_18_1","volume-title":"Tumors of the Breast, Chest, and Esophagus","author":"Pack GT","year":"1964"},{"key":"e_1_2_1_19_1","first-page":"22","article-title":"Treatment of carcinoma of the breast by modified radical mastectomy","volume":"140","author":"Papatestas AE","year":"1975","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1958.02990200024005"},{"key":"e_1_2_1_21_1","first-page":"117","volume-title":"Cancer of the Breast","author":"Spratt JS","year":"1967"},{"key":"e_1_2_1_22_1","first-page":"56","article-title":"Relationship of the size of colonic tumors to their cellular composition and biological behavior","volume":"10","author":"Spratt JS","year":"1960","journal-title":"Surg Forum"},{"key":"e_1_2_1_23_1","first-page":"271","article-title":"A report of 549 cases of breast cancer in women 35 years of age or younger","volume":"107","author":"Treves N","year":"1958","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_24_1","first-page":"4","article-title":"Partial mastectomy \u2013 unproven treatment for patients with potentially curable breast cancer","volume":"3","author":"Urban J","year":"1973","journal-title":"Clin Bull"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195901\/02)12:1<14::AID-CNCR2820120106>3.0.CO;2-L"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197112)28:6<1615::AID-CNCR2820280642>3.0.CO;2-W"},{"key":"e_1_2_1_27_1","first-page":"183","volume-title":"Proceedings of the Fifth National Cancer Conference","author":"Vermund L","year":"1964"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197402)33:2<349::AID-CNCR2820330208>3.0.CO;2-4"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930120208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930120208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:44:32Z","timestamp":1699836272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930120208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/jso.2930120208"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930120208","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}