{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:10:39Z","timestamp":1699837839746},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":10062,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two years follow\u2010up of 46 patients with colorectal carcinoma resected \u201cfor cure\u201d shows that of the nine patients with an elevated (&lt;5 ng\/ml) CEA plasma titer one to six months after surgery, only one, or 11%, had remained disease free. Of the 38 patients with normal (&lt;5 ng\/ml) plasma CEA, 27, or 71%, were free of disease two years after surgery. In another 85 patients presenting six months to ten years after resection \u201cfor cure\u201d of their colorectal carcinoma, normal CEA levels were found in 73, and only five, or 6.4%, of these presented with disease progression when followed for two years; of the 12 patients that presented with CEA values &gt;5 ng\/ml, disease progression was evident in eight or 67%; in eight patients with CEA levels of &gt;10 ng\/ml, the proportion of patients with disease progression increased to 87.5% (7\/8).<\/jats:p><jats:p>When a patient with a history of colorectal cancer, but seemingly free of disease, presents with levels not only repeatedly above normal (&gt;5 ng\/ml) but above the levels found in some nonmalignant conditions (&gt;10 ng\/ml), thorough re\u2010examination of the patient to locate the site of possible disease progression is indicated. In 14 such patients further diagnostic methods showed local recurrences in four, metastasis limited to the liver in six, and other metastasis in four.<\/jats:p><jats:p>In conclusion, in patients with colorectal carcinoma post operative elevated CEA plasma levels are a sign of poor prognosis. Consistently elevated CEA levels (&gt; 10 ng\/ml) are a stong indication of disease progression.<\/jats:p>","DOI":"10.1002\/jso.2930120405","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T06:36:03Z","timestamp":1171953363000},"page":"319-325","source":"Crossref","is-referenced-by-count":5,"title":["Predictive value of plasma CEA in patients with colorectal carcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"M.","family":"Koch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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Presented to the International Conference on the Clinical Uses of Carcinoembryonic Antigen Lexington Kentucky 1977."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930120405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930120405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:49:12Z","timestamp":1699836552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930120405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/jso.2930120405"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930120405","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}