{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:40:37Z","timestamp":1699846837313},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":9696,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of appropriate animal model systems has been proposed as a means of facilitating the study of human colorectal cancer. This report describes the development and use of a blind\u2010colorectal pouch in a carcinoma mouse model.<\/jats:p><jats:p>The blind\u2010pouch was prepared in C57BL\/6J mice by surgically exteriorizing the descending colon and producing two stomata in the abdominal wall. The proximal stoma served as an end colostomy and the distal stoma created as a mucous fistula. Surgical closure of the anus thus provided a colorectal pouch.<\/jats:p><jats:p>In pilot studies it was found that N\u2010methyl\u2010N\u2010nitrosourea (MNU) and radiation together but neither separately produced tumors in the pouch of surviving mice. Further, inoculation of C38 syngeneic tumor cell suspension into the pouch and immediate closure resulted in tumor takes within three to four weeks. The use of this model in carcinogenesis and the immunology of colon cancer simulate the human colorectal cancer problem more closely than previous animal models.<\/jats:p>","DOI":"10.1002\/jso.2930130107","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T06:34:25Z","timestamp":1171953265000},"page":"39-44","source":"Crossref","is-referenced-by-count":1,"title":["Mouse colostomy model for studies on large bowel cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"F. J.","family":"Volenec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Whitmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren J.","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/jnci\/56.2.207","article-title":"Immunotherapy of cancer in animals: Models or muddles?","volume":"56","author":"Bartlett GL","year":"1976","journal-title":"J Natl Cancer Inst."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03230460018013"},{"key":"e_1_2_1_4_2","first-page":"2434","article-title":"Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure","volume":"35","author":"Corbett TH","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","first-page":"1899","article-title":"Induction of colonic adenocarcinoma in the rat by x\u2010irradiation","volume":"38","author":"Denman DL","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91556-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196709)20:9<1466::AID-CNCR2820200913>3.0.CO;2-D"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2307\/3571427"},{"key":"e_1_2_1_9_2","first-page":"2874","article-title":"Colon carcinogenesis in germ\u2010free rats with intrarectal 1,2\u2010dimethylhydrazine and subcutaneous azoxymethane","volume":"36","author":"Reddy BS","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304938"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/jnci\/59.5.1537","article-title":"Murine colon adenocarcinoma Syngeneic orthotopic transplantation and subsequent hepatic metastases","volume":"59","author":"Tan MH","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_12_2","first-page":"940","article-title":"Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2\u2010dimethylhydrazine","volume":"33","author":"Thurnherr N","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","first-page":"505","article-title":"Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats","volume":"30","author":"Ward JM","year":"1974","journal-title":"Lab Invest"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197107)28:1<60::AID-CNCR2820280113>3.0.CO;2-U"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930130107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930130107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:27:52Z","timestamp":1699846072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930130107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/jso.2930130107"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930130107","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}