{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T12:10:18Z","timestamp":1699877418433},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9423,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1980,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The malignant carcinoid syndrome (MCS) is a rare complication of malignant carcinoid neoplasms, fewer than 200 cases having been reported since its description by Thorson in 1954. Its signs and symptoms vary with the site of the primary neoplasm, and MCS is now recognized as one member of the large family of endocrine tumors \u2010 APUDOMAS).<\/jats:p><jats:p>Although MCS remains uniformly fatal, significant palliation can be provided some patients with current surgical and chemotherapeutic management. All signs and symptoms in MCS, except evidence of the destruction of the tricuspid and pulmonic valves, can be reproduced experimentally. The factor causing this lethal complication has not been identified.<\/jats:p><jats:p>Two previously unreported cases of MCS, each from the gastrointestinal (GI) tract, are presented. This brings the world's total reported cases to approximately 210.<\/jats:p>","DOI":"10.1002\/jso.2930150210","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T07:09:23Z","timestamp":1171955363000},"page":"187-194","source":"Crossref","is-referenced-by-count":1,"title":["Malignant carcinoid syndrome: Two case reports"],"prefix":"10.1002","volume":"15","author":[{"given":"Joe L.","family":"Spann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Van Wormer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Sandlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(54)90152-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(56)90136-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/172910a0"},{"key":"e_1_2_1_5_2","first-page":"1955","article-title":"Argentaffinoma as an Endocrine Tumor","volume":"1","author":"Page IH","year":"1978","journal-title":"Lancet"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90298-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92907-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/17.5.303"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930080208"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90017-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.12.10.783"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90221-8"},{"issue":"2","key":"e_1_2_1_13_2","first-page":"223","article-title":"The management of carcinoid tumors of the gastrointestinal tract","volume":"145","author":"Welch JP","year":"1977","journal-title":"SGO"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40288-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196711232772101"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196676768"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-72-6-919"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.239.25.2686"},{"key":"e_1_2_1_19_2","first-page":"75","article-title":"Treatment of carcinoid syndrome by hemi\u2010hepatectomy with radical excision of primary lesion","volume":"128","author":"Billett DJ","year":"1974","journal-title":"Am J Surg"},{"key":"e_1_2_1_20_2","first-page":"1955","article-title":"Studies on indole metabolism in patients with malignant carcinoid","volume":"34","author":"Sjoerdsma A","year":"1974","journal-title":"J Clin Invest"},{"key":"e_1_2_1_21_2","first-page":"120","volume-title":"Surgical Endocrinology: Clinical Syndrome","author":"Freisen SR"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930150210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930150210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:24:21Z","timestamp":1699835061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930150210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1980,10]]}},"alternative-id":["10.1002\/jso.2930150210"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930150210","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,10]]}}}