{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:48:01Z","timestamp":1759837681030},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":9330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There were 487 patients treated for malignant melanoma of the upper extremities at the Pack Medical Group in New York City between 1939 and 1967 inclusive, fourth in frequency (14.7%) of total malignant melanomas treated here, being exceeded by malignant melanoma of the trunk (34%), head and neck (23%), and the lower extremities (20%). A 10\u2010year survival rate of 342 determinate patients was 63%. Fourteen percent of the patients who died of melanoma died between the fifth and tenth years, indicating the need to report survival at the 10\u2010year span. Survival was equal for the sexes (61% male and 64% female). The majority of the patients had infiltrating melanomas (Clark's Level 4 and 5) with a survival rate of 62%. Ten patients with superficial spreading melanomas (Clark's Level 2 and 3) and juvenile melanomas enjoyed a 100% 10\u2010year survival. The worst prognosis was for six patients with amelanotic melanoma in that only two of ten survived ten years or longer. The question of elective axillary dissection remains elusive. In 106 patients classified as clinical Stage I, elective axillary dissection was performed in 55 instances, and 26 patients had microscopic evidence of metastases. Their 10\u2010year survival rate was 65%, slightly higher than 16 patients in whom no elective axillary dissection was performed, among whom six later developed evidence of metastases, underwent therapeutic node dissections, and had a 10\u2010year survival of 56%. Radical amputation is occasionally indicated with great palliation and often prolongation of life.<\/jats:p>","DOI":"10.1002\/jso.2930160204","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T06:56:29Z","timestamp":1171954589000},"page":"125-143","source":"Crossref","is-referenced-by-count":14,"title":["Malignant melanoma of the upper extremities"],"prefix":"10.1002","volume":"16","author":[{"given":"Irving M.","family":"Ariel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"347","article-title":"The implantation of cancer\u2014An avoidable risk?","volume":"37","author":"Ackerman LL","year":"1955","journal-title":"Surgery"},{"key":"e_1_2_1_3_1","first-page":"601","article-title":"Tridimensional resection of malignant melanoma","volume":"139","author":"Ariel IM","year":"1974","journal-title":"Surg Gyn Obs"},{"key":"e_1_2_1_4_1","first-page":"135","volume-title":"Melanotic Tumors","author":"Attie JN","year":"1964"},{"key":"e_1_2_1_5_1","first-page":"1084","article-title":"Malignant melanoma of the feet and hands","volume":"42","author":"Booher RJ","year":"1957","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","first-page":"70","article-title":"Quarterectomy\u2014Its application in malignant melanoma","volume":"83","author":"Bowers RF","year":"1961","journal-title":"Arch Surg"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1960.01300050074014"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197511000-00007"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089167606200214"},{"key":"e_1_2_1_10_1","first-page":"333","article-title":"A clinical study of 250 patients with malignant melanoma","volume":"115","author":"Charalambidis PH","year":"1962","journal-title":"Surg Gynec Obst"},{"key":"e_1_2_1_11_1","first-page":"705","article-title":"The histogenesis and biologic behavior of primary malignant melanomas of the skin","volume":"29","author":"Clark WH","year":"1969","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197708000-00013"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196407)17:7<897::AID-CNCR2820170710>3.0.CO;2-Z"},{"key":"e_1_2_1_14_1","first-page":"183","volume-title":"Progress in Clinical Cancer","author":"Davis NC","year":"1977"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(62)90314-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197401000-00020"},{"key":"e_1_2_1_17_1","volume-title":"The Lymphatics in Cancer","author":"Haagensen CD","year":"1972"},{"key":"e_1_2_1_18_1","volume-title":"Melanoma. 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