{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:10:59Z","timestamp":1774368659596,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":9330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperthermia \u2a7e 42\u00b0C is tumoricidal in vitro and in many animal models, although such temperatures have only recently been achieved experimentally in some human cancers. A recently developed radio frequency device that provides safe hyperthermia to any depth without surface tissue injury now permits evaluation of the effects of hyperthermia on advanced human sarcomas. Twelve patients with large sarcomas located intraabdominally [7], in the chest wall [2], proximal extremity [2], and the neck [1], were evaluated in this study. Tumor types include liposarcoma [3], rhabdomyosarcoma [2], leiomyosarcoma [2], neurofibrosarcoma [2], and one each malignant mesothelioma, undifferentiated sarcoma, and osteosarcoma. Intratumor temperatures \u2a7e42\u00b0C were observed in all tumors, with virtually no normal tissue injury. Selective tumor heatin \u2a7e45\u00b0C occurred in 9\/12 (75%) and \u2a7e50\u00b0C in 6\/12 (50%). One to five weekly treatments \u2a7e50\u00b0C and ten daily treatments \u2a7e45\u00b0C resulted in significant tumor necrosis and pain relief in some patients. Hyperthermia of advanced sarcomas is possible with little host toxicity and may be of potential therapeutic benefit.<\/jats:p>","DOI":"10.1002\/jso.2930170202","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T07:58:52Z","timestamp":1171958332000},"page":"91-98","source":"Crossref","is-referenced-by-count":26,"title":["Radio frequency hyperthermia of advanced human sarcomas"],"prefix":"10.1002","volume":"17","author":[{"given":"F. Kristian","family":"Storm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"527","article-title":"Untersuchungen zur thermosensibilitat von tumor and normalzellen in vitro","volume":"17","author":"Bender E","year":"1966","journal-title":"Acta Biol Med Germ"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196709)20:9<1351::AID-CNCR2820200902>3.0.CO;2-#"},{"key":"e_1_2_1_4_2","first-page":"2568","article-title":"Selective lethal effect of supranormal temperatures on mouse sarcoma cells","volume":"33","author":"Giovanella BC","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","first-page":"771","article-title":"The selective inhibitory effect of hyperthermia on the metabolism and growth of malignant cells","volume":"15","author":"Muckle DS","year":"1978","journal-title":"Br J Cancer"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.28.2.75"},{"key":"e_1_2_1_7_2","unstructured":"DicksonJA(1975): Hyperthermia and laboratory animal systems: Chairman's address. 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Washington DC April 28\u201330.Am Coll Radpp.105\u2013106."},{"key":"e_1_2_1_8_2","first-page":"301","article-title":"Technology for the hyperthermic treatment for large solid tumors at 50\u00b0C","volume":"3","author":"Dickson JA","year":"1977","journal-title":"Clin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(72)90085-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1927.tb00237.x"},{"key":"e_1_2_1_11_2","first-page":"2245","article-title":"Hyperthermia in cancer treatment: Normal tissue and solid tumor effects in animal models and clinical trials","volume":"39","author":"Storm FK","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.235.20.2198"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90258-7"},{"key":"e_1_2_1_14_2","first-page":"2304","article-title":"Regional blood flow in human tumors","volume":"39","author":"Mantyla MJ","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","unstructured":"OlesonJR StaufferPR CetasTC et al (1981): Magnetic induction heating in heterogenous material.J Nat Cancer Inst (in press)."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801015)46:8<1849::AID-CNCR2820460824>3.0.CO;2-S"},{"key":"e_1_2_1_17_2","unstructured":"StormFK MortonDL EilberFR et al (1988: Sarcoma: Etiology and advances in therapy with immunotherapy limb salvage and hyperthermia.Seminars in Oncol (in press)."},{"key":"e_1_2_1_18_2","first-page":"33","volume-title":"Advances in Surgery","author":"Storm FK","year":"1979"},{"key":"e_1_2_1_19_2","unstructured":"StormFK MortonKL KaiserLR et al (1988: Clinical radiofrequency hyperthermia: A review.J Nat Cancer Inst In press."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930170202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930170202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:14:43Z","timestamp":1699827283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930170202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jso.2930170202"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930170202","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}