{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:34:58Z","timestamp":1792661698058,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":9330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The undescended testis carries an increased risk of cancer; however, the exact individual risk of a cryptorchist during his life to develop cancer is unknown. The risk of developing cancer can be calculated from three important figures: (a) the number of cryptorchists in the population; (b) the number of malignant testicular tumors found in undescended testicles; and (c) the number of testicular tumors per annum. In the literature, a 48 times increased chance to develop testicular cancer is accepted; it is a high risk which is contrary to the fact that a malignant cryptorchid testis is a very rare disease. Based on the estimated risk for the cryptorchist in the Netherlands to develop testicular cancer, this article criticizes the value of the figures that are generally used to calculate the individual risk; it is concluded that even today the exact risk is unknown. In giving advice concerning the management of undescended testis, one must appreciate not only the supposed cancer risk, but also take into consideration morbidity and mortality after prophylactic orchidectomy and improved cure rates after electively treated testicular tumors.<\/jats:p>","DOI":"10.1002\/jso.2930170304","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T07:43:21Z","timestamp":1171957401000},"page":"219-223","source":"Crossref","is-referenced-by-count":13,"title":["Management of the undescended testis in relation to the development of cancer"],"prefix":"10.1002","volume":"17","author":[{"given":"K.","family":"Welvaart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G. P.","family":"Tijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","article-title":"Studies in malignant testis tumors","volume":"71","author":"Gilbert JB","year":"1940","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)67853-4","article-title":"The cryptorchid problem","volume":"71","author":"Grove JS","year":"1954","journal-title":"J Urol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-5347(17)66088-9","article-title":"The incidence of malignant growth of the undescended testicle: A reply and re\u2010evaluation","volume":"81","author":"Campbell HE","year":"1959","journal-title":"J Urol"},{"key":"e_1_2_1_5_1","article-title":"Classification and frequency of testicular tumours. In: \u201cThe Pathology of Testicular Tumors.\u201d","volume":"36","author":"Collins DH","year":"1964","journal-title":"Brit J Urol"},{"key":"e_1_2_1_6_1","first-page":"25","article-title":"Management of the undescended testis","volume":"4","author":"Whitaker RH","year":"1970","journal-title":"Brit J Hosp Med"},{"key":"e_1_2_1_7_1","volume-title":"Testicular Tumors","author":"Johnson DE","year":"1972"},{"key":"e_1_2_1_8_1","unstructured":"DinnerM SpitzL:The relationship of testicular tumours to maldescent. S.\u2010A. Mediese Tijdschrif 1974."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)69080-3","article-title":"Malignancy in cryptorchidism","volume":"61","author":"Carroll WA","year":"1949","journal-title":"J Urol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)74120-1","article-title":"New grouwths developing in undescended testicles","volume":"5","author":"Cunningham JH","year":"1921","journal-title":"J Urol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)65981-0","article-title":"Malignant tumor of testis occurring 29 years after orchiopexy: Case report and review of the literature","volume":"81","author":"Sumner WA","year":"1959","journal-title":"J Urol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196702000-00021"},{"key":"e_1_2_1_13_1","article-title":"Cryptorchism and testicular tumorgenesis","volume":"63","author":"Johnson DE","year":"1968","journal-title":"Surgery"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-5347(17)63068-4","article-title":"Carcinoma of the testis following orchiopexy","volume":"97","author":"Altman BL","year":"1967","journal-title":"J Urol"},{"key":"e_1_2_1_15_1","article-title":"Malignant degeneration of cryptorchid testes following orchiopexy","volume":"112","author":"Grand Gehring G","year":"1974","journal-title":"J Urol"},{"key":"e_1_2_1_16_1","volume-title":"Tumors of the Testicle","author":"Blandy JP","year":"1970"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/56.4.731","article-title":"Cryptorchidism, hernia, and cancer of the testis","volume":"56","author":"Morrison AS","year":"1976","journal-title":"J Nat Cancer Instit"},{"key":"e_1_2_1_18_1","volume-title":"The National Halothane Study","author":"Bunker JP","year":"1969"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930170304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930170304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:21:01Z","timestamp":1699827661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930170304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jso.2930170304"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930170304","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}