{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T05:40:10Z","timestamp":1699854010635},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":9330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metastatic capacity of rat mammary tumors induced with N\u2010nitrosomethyl urea was tested in BUF\/N inbred female rats by successive transplantation. After the first and second passage, tumor cells appeared diffusely distributed throughout the bone marrow and spleen, confirming results reported by others; no other metastases were observed. After six successive transplantations, large, well\u2010defined tumor nodules were observed in the liver, spleen, lung, and the peritoneal surface of the intestines in 40% of the injected animals. The morphology of the primary and metastatic tumors was compared by light microscopy. The tumors appeared to be adenocarcinomas with differing degrees of differentiation. No morphlogical differences could be observed between the primary and the metastatic tumors.<\/jats:p>","DOI":"10.1002\/jso.2930180104","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T07:40:20Z","timestamp":1171957220000},"page":"21-26","source":"Crossref","is-referenced-by-count":0,"title":["Pathology of metastasizing tumors in nitrosomethyl urea\u2010induced rat mammary carcinoma"],"prefix":"10.1002","volume":"18","author":[{"given":"Luna","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Nassauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidore","family":"Faiferman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bimal C.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1739","article-title":"Regional differences in the incidence and growth of mouse tumors following intradermal or subcutaneous inoculation","volume":"38","author":"Auerbach R","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_2","first-page":"728","article-title":"Murine and rat mammary tumors as models for the immunological study of human breast cancer","volume":"36","author":"Brennan MJ","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","volume-title":"Secondary Spread of Tumors","author":"Carter RL","year":"1978"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.887927"},{"key":"e_1_2_1_6_2","first-page":"10","article-title":"Ultrastructural study of membrane glycocalyx in primary and metastatic rat mammary carcinoma","volume":"20","author":"Ghosh L","year":"1979","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_7_2","first-page":"401","article-title":"N\u2010nitrosomethyl urea as mammary gland carcinogen in rats","volume":"54","author":"Gullino PM","year":"1975","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.167.3914.72"},{"key":"e_1_2_1_9_2","first-page":"73","article-title":"Pathogenesis of spontaneously metastasizing mammary carcinoma in rats","volume":"20","author":"Kim U","year":"1977","journal-title":"Gann"},{"key":"e_1_2_1_10_2","volume-title":"The Spread of Tumours in the Human Body","author":"Willis RA","year":"1973"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930180104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930180104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T05:01:47Z","timestamp":1699851707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930180104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jso.2930180104"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930180104","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}